血浆D-二聚体检测在肺炎支原体肺炎中的临床意义

目的探讨血浆D-二聚体水平在肺炎支原体肺炎患者的表达和临床意义。方法选取首都医科大学附属北京安贞医院120例住院治疗的社区获得性肺炎患者，按随机数字表法分为肺炎支原体肺炎组（51例）和其他肺炎组（69例），同时选择58例健康体检者作为对照组。检测3组患者血浆D-二聚体，比较3组D-二聚体水平的差异以及D-二聚体的阳性率。结果肺炎支原体肺炎组以及其他肺炎组的血浆D-二聚体水平均高于对照组水平（324±159）、（281±110）μg/L比（73±43）μg／L]，差异有统计学意义（P〈0．05）；肺炎支原体肺炎组的D-二聚体水平与其他肺炎组比较，差异无统计学意义（P〉0．05），但怖炎支原体肺炎组的血浆D-二聚体阳性率明显高于其他肺炎组35．3％（18／51）比17．4％（12／69）]，差异有统计学意义（P〈0．05）。结论社区获得性肺炎尤其是怖炎支原体肺炎常可引起凝血机制异常，导致体内出现高凝状态，进而引起血栓形成的可能，故对于肺炎支原体肺炎的患者需高度关注血浆D-二聚体的变化。

Clinical significance of D-dimer in mycoplasma pneumoniae pneumonia

Objective To investigate the plasma D-dimer level in the expression of mycoplasma pneumon- iae pneumonia. Methods Totally 120 hospitalized patients with community acquired pneumonia in Beijing Anzhen hospital were divided into myeoplasma pneumoniae pneumonia group （51 cases） and other pneumonia group （69 cases）; healthy people （58 cases） were selected as the control group. The plasma D-dimer of three groups was detected. The D-dimer level and positive rate were compared. Results The plasma D-dimer level of mycoplasma pneumoniae pneumonia group and other pneumonia group was higher than that of the control group （ 324 ＋ 159 ）, （ 281 ＋ 110 ） μg/L vs （ 73 ＋ 43 ）μg/L ] （ P 〈 0.05 ）. The D-dimer level of mycoplasma pneumoniae pneumonia group had no significant difference compared with other pneumonia groups （ P 〉 0.05 ） ; hut positive rate of mycoplasma pneumoniae pneumonia group was significantly higher than that of the other pneumonia group 35. 3% （18/51） vs 17. 4 % （12/69）] and the difference was statistically significant （P 〈 0. 05）. Conclusion Community acquired pneumonia, especially myeoplasma pneumoniae pneumonia, can oflen cause dysfunction of coagulation, result in high agglutination condition and may cause thrombosis. Key words] Mycoplasma pneumoniae pneumonia; D-dimer; Thrombus