妊娠合并甲状腺机能亢进症临床探讨

目的探讨妊娠合并甲亢患者孕期病情变化,以及丙基硫氧嘧啶治疗对妊娠及胎儿的影响。方法对42例妊娠合并甲亢病例进行回顾性分析。结果42例中,妊娠期出现明显甲亢表现者29例,20例经正规治疗,甲亢控制好,娩出正常新生儿,仅1例出现一过性甲状腺功能减退;9例未正规治疗或未治疗者,甲亢未能控制,发生自发流产1例,人工流产4例,低体重儿3例,1例因并发妊娠高血压综合征和甲亢危象而放弃治疗。结论妊娠各期均可发生甲亢或甲亢复发、加重。甲亢可致不良妊娠结局并对胎儿及新生儿产生不良影响。丙基硫氧嘧啶治疗明显改善预后。

Clinical study on hyperthyroidism in pregnancy

Objective To study the changes of thyroid function of hyperthyroidism in pregnancies,and the effects on gestation and the fetus with propylthiouracil(PTU).Methods Clinical data of 42 cases of hyperthyroidism in pregnancies were analyzed retrospectively.Results There were overt clinical symptoms of hyperthyroidism in 29cases of 42 cases.The clinical symptoms of hyperthyroidism in 20 cases were controlled after treatment,and newborns were healthy(only one case with temporary neonatal hypothyroidism).There were 9 cases did not controlled(1 case with spontaneous abortion,4 cases with artificial abortions,3 cases with low-weight newborns,1 case giving up treatment for hypertension syndrome of pregnancy and thyrotoxic crisis).Conclusion Hyperthyroidism can be induced,recurred or worsened during different gestation period.It can result in serious outcome in hyperthyroidism of pregnancy,and bad effects on the fetus and the neonate,and it can be obviously improved the progonosis with PTU treatment.