豚鼠鼓室导抗图正常值测试及结果分析

目的研究豚鼠鼓室导抗图（tympanogram）各个测试项目的正常值范围及不同性别、耳别之间的差异。方法选取ABR反应阈正常、无耳科疾病的正常豚鼠40只，在麻醉状态下测试其鼓室导抗图，并对不同性别、耳别的各个测试项目的结果进行比较。结果所有鼓室导抗图均符合Jerger分类法中的“A”型曲线，其等效外耳道容积约为0．09±0．02ml，静态声顺值约为0．10±0．03ml，坡度约为0．14±0．06ml，峰压值约为一99．44±75．06daPa。等效外耳道容积在性别间的差异具有统计学意义（P=0．012），而静态声顺值、坡度和峰压值差异均无统计学意义（P〉0．05）。左右耳间各指标差异均无统计学意义（P〉0．05）。结论雄性与雌性豚鼠鼓室导抗图的等效外耳道容积存在显著性差异，其他各指标的结果在不同性别、耳别之间无明显差异。

The Establishment of Normal Values of Tympanogram in Guinea Pigs

Objective To investigate the range of normal values of tympanometry of guinea pigs and the possible differences associated with genders and ears. Methods Included in this study were 40 guinea pigs with nor-mal hearing and no ear diseases. Under the anesthetized condition, each guinea pig's tympanogram was recorded, and their values were studied associated with different genders and ears. Results The tympanograms thus obtained were all type A. For all the tympanograms of 80 ears, the equivalent canal volume was about 0.09±0. 02 ml, the static compliance was 0.10 ±0.03 ml, the gradient was 0.14 ±0.06 ml, and the pressure of the peak admittance was -99.44±75.06 daPa . The findings of different gender groups yielded statistic differences in the values of e-quivalent canal volume (P=0. 012) but not in static compliance, gradient and peak admittance pressure (P>0. 05). Typical tympanograms were recorded for the both ears in 40 guinea pigs at the same time. There were no binaural differences (P>0.05). Conclusion The results show significant differences in the equivalent canal volumes be-tween male and female guinea pigs. These tympanograms may serve as a guide to detect middle ear dysfunctions in guinea pigs.