HLA-B27对强直性脊柱炎的诊断价值

目的 了解人类白细胞抗原-B27（HLAB27）对强直性脊柱炎（AS）的诊断价值和在病情活动中的作用。方法 对2000～2002年病案资料中38例HLA-B27阴性的AS患者与92例HLA—B27阳性患者，进行临床表现和实验室的特殊检查结果分析。结果 B27阴性组的严重的髋关节病变、窦缓和／或传导阻滞、合并类风湿性关节炎及其它合并症（颈椎病、骨关节炎、腰椎间盘突出症等）的比率均明显低于B27阳性组。疾病活动性指标如血沉（ESR）、C-反应蛋白（CRP）在B27阴性组中明显低于B27阳性组。结论 B27检查结果对于AS疑似患者有助于明确诊断；而B27阴性的AS患者病情较轻，预后良好。

Diagnostic value of HLA-B27 on ankylosing spondylitis

Objective To discuss the function of HLA-B27 in diagnosis of ankylosing spondylitis (AS).Methods Thirty-eight cases of AS with HLA-B27 negative and 92 cases with HLA-B27 positive were analyzed by clinical expression and special examination.Results The complication ratio in group of HLA-B27 negative was lower than that of HLA-B27 positive;active index,such as ESR and CRP,in group of HLA-B27 negative was lower than that of HLA-B27 positive.Conclusion AS patients of HLA-B27 negative have a mild nature and better prognosis,and HLA-B27 detection is helpful for definite diagnosis to AS suspected cases.