Molecular characterization of a new D‐ ‐ haplotype in a Comorian man |
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Authors: | M. Silvy S. Chapel‐Fernandes S. Beley C. Durousseau T. Granier J. P. Zappitelli P. Bailly J. Chiaroni |
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Affiliation: | établissement Fran?ais du Sang Alpes Méditerranée, Laboratoire d’Hématologie Moléculaire, UMR 7268, Aix‐Marseille Université, France |
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Abstract: | The D‐ ‐ phenotype is a genetic variant of the Rh blood group system. It expresses D antigen but lacks C, c, E and e antigens. In D‐ ‐ phenotype, the RHCE coding region is extensively modified by RHD sequence replacement, nucleotide deletion or splice‐site changes. This article reports the identification of a new D‐ ‐ haplotype in a Comorian man. It exhibits a hybrid gene in which RHCE gene exons 3–8 have been replaced by RHD sequences on the RHCE * C allele background. This allele is associated with no expression of c/C and e/E antigens and overexpression of RhD antigen. |
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Keywords: | RHD ‐ ‐ haplotype RhD epitope density RhD overexpression zygosity |
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