Inflammatory cytokine levels in patients with periodontitis and/or coronary heart disease |
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Authors: | Haihua Zhu Xiaolong Lin Pei Zheng Hui Chen |
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Affiliation: | Department of Conservative Dentistry and Periodontics, Affiliated Hospital of Stomatology, College of Medicine, Zhejiang University, China |
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Abstract: | The purpose of this study was to investigate systemic and local levels of four classic inflammatory cytokines (IL-1β, MCP-1, VEGF, PDGF) in patients with periodontitis and coronary heart disease (CHD). 109 volunteers were enrolled and the condition of their periodontal tissue and coronary artery were assessed. The patients were then divided into four distinct groups: periodontitis only, CHD only, periodontitis with CHD, and healthy controls. Gingival crevicular fluid (GCF) and venous blood were collected. The concentrations of cytokines were detected meanwhile by specific ELISA. The IL-1β and MCP-1 concentrations in the serum and GCF of the three disease groups were significantly higher than those in the control group (P ≤ 0.05). Serum VEGF concentrations of the patients with existing disease was lower than that of the controls. VEGF levels in the GCF of all disease groups were significantly higher than that of the control group (P ≤ 0.05). |
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Keywords: | Interleukin-1β (IL-1β ), monocyte chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), periodontal disease, coronary heart disease |
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