非小细胞肺癌再程放疗联合化疗的临床疗效观察

目的:比较三维适形放射治疗联合化疗和单纯三维适形放射治疗治疗复发的非小细胞肺癌的近期疗效及不良反应。方法:回顾性收集2011年6月至2017年10月入住我院的52例复发的非小细胞肺癌患者。治疗组:三维适形放射治疗+TP方案。对照组:三维适形放射治疗。结果:治疗组患者总有效率为50.00%（14/28），对照组患者总有效率为20.83%（5/24），两组患者近期总有效率比较差异有统计学意义（P＜0.05）。治疗组不良反应的发生率消化道反应最为明显，达到85.71%（24/28），与对照组比较差异有显著统计学差异（P＜0.01）。骨髓抑制的发生率为53.57%（15/28），与对照组比较差异有统计学意义（P＜0.05）。放射性肺炎、肝功能损害、放射性食管炎，皮肤反应两组均无明显差异（P＞0.05）。 结论:小细胞肺癌复发后，在身体条件允许的情况下，再程放疗联合化疗疗效比单纯放疗疗效高，不良反应可接受，值得临床进一步研究和推广。

Clinical efficacy of reradiotherapy combined with chemotherapy in patients with non-small cell lung cancer

Objective:To compare the short-term efficacy and adverse effects of three dimensional conformable radiotherapy combined with chemotherapy and simple three dimensional conformal radiotherapy in the treatment of recurrent non-small cell lung cancer.Methods:52 patients with recurrent non-small cell lung cancer (NSCLC) admitted to our hospital from June 2011 to October 2017 were retrospectively collected.Treatment group:Three-dimensional conformal radiotherapy TP regimen.Control group:Three dimensional conformal radiotherapy.Results:The total effective rate was 50.00%(14/28) in the treatment group and 20.83%(5/24) in the control group.The incidence of digestive tract reaction in treatment group was the most obvious,reaching 85.71%(24/28).The incidence of myelosuppression was 53.57%(15/28).There was no significant difference between the two groups in radiation pneumonitism,hepatic injury,radiation esophagitis and skin reaction(P＜0.05).Conclusion:The combined chemotherapy with radiotherapy combined with chemotherapy is more effective than simple radiotherapy and the side reaction is acceptable after the recurrence of small cell lung cancer.It is worthy of clinical investigation and popularization.