基于数据库分析KIF23在乳腺癌中的表达及预后意义

目的 基于数据库分析驱动蛋白超家族23 （KIF23） 在乳腺癌中的表达及意义。方法 利用Oncomine数据库和GCBI数据库分析KIF23基因在正常乳腺组织及乳腺癌中的表达差异,并对相关研究进行综合分析。通过 Kaplan-Meier Plotter数据库分析KIF23表达水平与乳腺癌患者各项生存预后指标： 无复发生存 （RFS）、 总生存 （OS）、无远处复发生存 （DMFS）、 复发后生存 （PPS） 之间的关系。结果 Oncomine数据库显示， KIF23在乳腺癌中较正常组织表达增高。综合分析39项关于正常乳腺组织和乳腺癌组织中KIF23表达水平的研究发现， KIF23基因在乳腺癌所有差异表达基因中的排名中位数为900.0， 差异有统计学意义 （P＜0.05）， KIF23在乳腺癌中高表达。KIF23在23项浸润性和4项非浸润性乳腺癌的不同病理类型中均高表达， 且差异表达基因的中位数值排名有统计学意义 （P＜0.05）。 GCBI数据库亦显示， KIF23在乳腺癌中的表达水平 （587.27） 高于正常乳腺组织 （90.89）， 差异有统计学意义 （P＜ 0.05）。Kaplan-Meier Plotter数据库分析结果表明， KIF23高表达患者的RFS、 OS、 DMFS和PPS劣于低表达患者， 且分层分析发现， 在ER （+） 组中KIF23高表达患者的上述生存预后指标均较差。结论 KIF23在乳腺癌中高表达， 且与恶性乳腺癌患者不良预后相关， 可能对乳腺癌的诊断、 治疗及预后评估具有重要意义。

Expression and prognostic significance of KIF23 in breast cancer based on database analysis

Objective To analyze the expression and significance of kinesin family member 23 (KIF23) in breast cancer based on databases mining. Methods In this study, the differential expression of KIF23 gene in breast cancer and normal tissues was compared using the Oncomine and GCBI databases, and then its expression level was overall analyzed. The relationship between KIF23 expression level and prognosis survival, including relapse-free survival (RFS), overall survival (OS), distant metastases-free survival (DMFS) and post-progression survival (PPS), in breast cancer patients were analyzed by the Kaplan-Meier Plotter database. Results It was discovered that KIF23 was more abundantly expressed in breast cancer and a total of 39 studies in the Oncomine database were involved in the expression level of KIF23 in breast cancer and normal tissues. The median rank of KIF23 gene was 900.0 in all differentially expressed genes of breast cancer (P＜0.05). The expression levels of KIF23 were higher in 23 invasive and 4 non-invasive samples of breast cancer, the median rank of differentially expressed genes was statistically significant (P＜0.05). KIF23 was highly expressed in breast cancer (587.27) compared with that of normal tissues (90.89) after integrated analysis (P＜0.05), which was also proved in the GCBI. In addition, Kaplan-Meier Plotter database analysis indicated that the high expression of KIF23 was closely associated with poor survival. Further analysis showed that the expression levels of survival indicators in ER (+) group were statistically significant. Conclusion KIF23 is highly expressed in breast cancer and is associated with poor prognosis in patients, which may be important for the diagnosis, treatment and prognosis assessment of breast cancer.