益肠促愈方辅助西药治疗宫颈癌放疗后放射性肠炎疗效观察

目的:探讨益肠促愈方辅助西药治疗宫颈癌放疗后放射性肠炎临床疗效。方法:研究对象选取我院2015年7月至2017年7月收治宫颈癌放疗后放射性肠炎患者共100例，以随机数字表法分为对照组（50例）和中西医组（50例），分别给予西药单用和在此基础上加用益肠促愈方辅助治疗，比较两组综合疗效，内镜疗效，治疗前后主要证候评分、日常生活质量评分、转化生长因子β1（transforming growth factor β1，TGF-β1）水平及药物毒副反应发生率。结果:中西医组综合疗效和内镜疗效均显著优于对照组（P<0.05）；中西医组治疗后主要证候评分显著低于对照组、治疗前（P<0.05）；中西医组治疗后EORTC QOL-C30量表评分均显著高于对照组、治疗前（P<0.05）；中西医组治疗后TGF-β1水平显著低于对照组、治疗前（P<0.05）；同时两组药物毒副反应发生率比较差异无统计学意义（P>0.05）。结论:益肠促愈方辅助西药治疗宫颈癌放疗后放射性肠炎可有效减轻消化道和全身症状，促进肠黏膜损伤修复，调节TGF-β1水平。

Clinical effects observation of Yichangcuyu decoction combined with western medicine in the treatment of patients with radiation enteritis secondary to radiotherapy for cervical cancer

Objective:To investigate the clinical effects of Yichangcuyu decoction combined with western medicine in the treatment of patients with radiation enteritis secondary to radiotherapy for cervical cancer.Methods:100 patients with radiation enteritis secondary to radiotherapy for cervical cancer were chosen in the period from July 2015 to July 2017 in our hospital and randomly divided into both group including control group(50 cases) with western medicine used alone and tradition Chinese medicine（TCM） combined with western medicine group(50 cases)with Yichangcuyu decoction combined with western medicine.And the comprehensive clinical effects，endoscopic clinical effects，the main syndrome score，daily life quality score and the levels of transforming growth factor β1（TGF-β1） before and after treatment and the incidence of drugs toxicity and side effects of both groups were compared.Results:The comprehensive clinical effects and endoscopic clinical effects of TCM combined with western medicine group were significant better than control group（P<0.05）.The main syndrome score after treatment of TCM combined with western medicine group were significant lower than control group and before treatment（P<0.05）.The EORTC QOL-C30 scores after treatment of TCM combined with western medicine group were significant higher than control group and before treatment（P<0.05）.The levels of TGF-β1 after treatment of TCM combined with western medicine group were significant lower than control group and before treatment（P<0.05）.There was no significant difference in the incidence of drugs toxicity and side effects between 2 groups（P>0.05）.Conclusion:Yichangcuyu decoction combined with western medicine in the treatment of patients with radiation enteritis secondary to radiotherapy for cervical cancer can efficiently relieve the symptoms of gastrointestinal and systemic，promote the repair process of normal mucosa damage，improve the quality of daily life，regulate the levels of TGF-β1 and not aggravate the drugs toxicity and side effects.