| 肺癌防治动物模型研究进展 |
| |
| 引用本文： | 董昌盛1,' target='_blank'>2,毕 凌3,阙祖俊1,田建辉1,' target='_blank'>2. 肺癌防治动物模型研究进展[J]. 现代肿瘤医学, 2019, 0(5): 873-878. DOI: 10.3969/j.issn.1672-4992.2019.05.040 |
| |
| 作者姓名： | 董昌盛1 ' target='_blank'>2 毕 凌3 阙祖俊1 田建辉1 ' target='_blank'>2 |
| |
| 作者单位： | 1.上海市中医药研究院中医肿瘤研究所，上海 200032；2.上海中医药大学附属龙华医院肿瘤科，上海 200032；3.上海中医药大学研究生院，上海 201203 |
| |
| 基金项目： | National Natural Science Foundation of China(No.81403356，81774166）；国家自然科学基金（编号:81403356，81774166）；上海市卫计委市级医疗卫生优秀学科带头人培养计划资助项目(编号:2017BR044)；上海市卫计委科研课题面上项目（编号:201640178）；杏林中青年人才（杏林青年学者）培养项目（编号:RC-2017-02-02） |
| |
| 摘 要： | 精准模拟肺癌发病病理过程的动物模型是促进肺癌基础和转化研究的关键，而目前常用的皮下移植瘤模型难以体现肺脏的基质环境特征。小动物活体成像技术可客观、动态地评价肺癌的肿瘤负荷变化及转移发生情况，在此基础上建立的肺癌原位移植瘤动物模型可解决以上难题，充分体现肺癌的发病学特征。而人源性肿瘤组织异种移植(patient derived tumor xenograft，PDTX)原位模型和类器官模型也可部分体现肿瘤微环境和肿瘤细胞的异质性，均已成为该领域的重要发展方向。
|
| 关 键 词： | 肺癌 动物模型 人源性肿瘤组织异种移植 |
Research progress of animal models of lung cancer |
| |
| Dong Changsheng1,' target='_blank'>2,Bi Ling3,Que Zujun1,Tian Jianhui1,' target='_blank'>2. Research progress of animal models of lung cancer[J]. Journal of Modern Oncology, 2019, 0(5): 873-878. DOI: 10.3969/j.issn.1672-4992.2019.05.040 |
| |
| Authors: | Dong Changsheng1 ' target='_blank'>2 Bi Ling3 Que Zujun1 Tian Jianhui1 ' target='_blank'>2 |
| |
| Affiliation: | 1.Tumor Institute of Traditional Chinese Medicine Affiliated to Shanghai Academy of Traditional Chinese Medicine and Pharmacology，Shanghai 200032，China；2.Department of Oncology，Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 200032，China；3.Graduate School，Shanghai University of Traditional Chinese Medicine，Shanghai 201203，China. |
| |
| Abstract: | Lack of a suitable prevention and treatment animal model of lung cancer is a major obstacle for basic research and drug development.The existing xenotrans-planted subcutaneous tumor model cannot reflect the actual role in the pathogenes is of lung cancer and the incidence of lung cancer and actual pathological process on microenvironment.Orthotopic transplant tumor model can solve the above problems，because it can fully embodies the characteristics of lung cancer biology.Combined with the small animal in vivo imaging technology can objectively evaluate dynamic changes in lung tumor burden and the actual metastasis，it will be the main direction of the development of an animal model of lung cancer in future.Patient derived tumor xenograft（PDTX) and organ like models can also partially reflect the heterogeneity of tumor microenvironment and tumor cells，which have become an important trend in this field. |
| |
| Keywords: | lung cancer animal model PDTX |
|
| 点击此处可从《现代肿瘤医学》浏览原始摘要信息 |
|
点击此处可从《现代肿瘤医学》下载免费的PDF全文 |
