| ASAP3在乳腺浸润性导管癌中的表达及临床意义 |
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| 引用本文： | 王晓兰,毛晓韵,范垂锋,金 锋,张殿龙.ASAP3在乳腺浸润性导管癌中的表达及临床意义[J].现代肿瘤医学,2019,0(3):396-399. |
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| 作者姓名： | 王晓兰 毛晓韵 范垂锋 金 锋 张殿龙 |
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| 作者单位： | 1.大连大学附属中山医院乳腺甲状腺外科，辽宁 大连 116001;
2.中国医科大学附属第一医院乳腺外科，辽宁 沈阳 110001;
3.中国医科大学基础医学院病理学教研室，辽宁 沈阳 110001 |
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| 基金项目： | National Natural Science Foundation of China(No.81201886，81773163）；国家自然科学基金资助项目（编号:81201886，81773163） |
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| 摘 要： | 目的:研究乳腺浸润性导管癌中ASAP3的表达，分析其与乳腺浸润性导管癌临床病理学特征的关系。方法:采用免疫组化方法检测139例乳腺浸润性导管癌及配对50例癌旁乳腺组织中ASAP3的表达情况，并分析ASAP3表达与乳腺癌患者临床病理因素及弹性评分的相关性。结果:ASAP3在乳腺浸润性导管癌中的阳性表达率为59.0%（82/139），在配对的癌旁组织中的阳性表达率为4.0%（2/50），ASAP3在乳腺癌中的表达明显高于癌旁乳腺组织(P<0.01)。ASAP3表达与乳腺浸润性导管癌的淋巴结转移、原发灶组织学分级及TNM分期相关（P<0.05），与肿瘤大小、患者年龄、月经状态无明显相关性（P>0.05）。ASAP3与乳腺癌原发灶弹性评分相关（P<0.05）。结论:ASAP3是乳腺浸润性导管癌发生及进展的重要分子，且与肿瘤硬度有相关性。
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| 关 键 词： | 乳腺浸润性导管癌 ASAP3 肿瘤弹性 |
Expression and clinical significance of ASAP3 in breast infiltrative ductal cancer |
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| Wang Xiaolan,Mao Xiaoyun,Fan Chuifeng,Jin Feng,Zhang Dianlong.Expression and clinical significance of ASAP3 in breast infiltrative ductal cancer[J].Journal of Modern Oncology,2019,0(3):396-399. |
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| Authors: | Wang Xiaolan Mao Xiaoyun Fan Chuifeng Jin Feng Zhang Dianlong |
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| Institution: | 1.Department of Breast and Thyroid Surgery，the Affiliated Zhongshan Hospital of Dalian University，Liaoning Dalian 116001，China； 2.Department of Breast Surgery，the First Hospital of China Medical University，Liaoning Shenyang 110001，China；3.Institute of Pathology and Pathophysiology，the College of Basic Medical Sciences，China Medical University，Liaoning Shenyang 110001，China. |
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| Abstract: | Objective:To discuss the expression of ASAP3 in breast invasive ductal cancer，further to illustrate the role of ASAP3 in breast cancer clinicohistological characteristics and tumor tissue elasticity.Methods:The expression of ASAP3 was investigated in 139 invasive ductal breast cancer and 50 paired para-tumor tissue by immunohistochemistry.Results:The ASAP3 positive rate was 59.0%（82/139） in breast cancer and 4.0%（2/50） in paired para-tumor tissues.ASAP3 expression was significantly associated with lymph node metastasis，histological grade and TNM stage（P<0.05)，and no correlation with tumor size,age and menopausal status（P>0.05).The results of immunohistochemistry demonstrated ASAP3 correlated with the tumor tissue elasticity（P<0.05).Conclusion:It suggested that the ASAP3 played important role in the occurrence and progress of breast cancer，and related with the tumor tissue elasticity（or stiffness). |
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| Keywords: | breast invasive ductal cancer ASAP3 tissue elasticity |
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