基因多态性与结直肠癌化疗毒性及疗效的关系

摘要： 结直肠癌是发病率和死亡率双高的一种癌症， 化疗是临床中最常用的治疗手段之一， 但不同患者对同样的化疗方案的不良反应和药物敏感性相差很大。越来越多的研究证实这种个体差异与基因多态性密切相关。目前， 基因多态性在结直肠癌靶向治疗中的研究已经普遍被人们接受， 在化疗中的研究也越来越广泛。联合化疗在结直肠癌临床治疗中效果更显著， 明确这些基因多态性位点对于结直肠癌的精准化疗及联合化疗等治疗方法具有重要的指导意义。本文对临床上结直肠癌常用的化疗药物和化疗方案相关的基因多态性及其意义做一综述。

Relationship between gene polymorphism and the toxicity and efficacy of chemotherapy in colorectal cancer

Abstract：Colorectal cancer is a kind of cancer with both high morbidity and mortality. Chemotherapy is one of the most commonly used treatments in clinic, however toxicity and drug sensitivity to the same chemotherapy regimen are vary greatly in different patients. More and more studies have confirmed that this individual difference is closely related to gene polymorphism. At present, the research of gene polymorphism in targeted therapy of colorectal cancer has been widely accepted, and the research in chemotherapy has become more and more extensive. Combined chemotherapy has significant effect in clinical treatment of colorectal cancer. Therefore, the identification of these gene polymorphisms has important guiding significance for precise chemotherapy and combined chemotherapy of colorectal cancer. This article reviewed the gene polymorphisms associated with chemotherapeutics drugs and regimens commonly used in colorectal cancer, as well as their clinical significances.