腹腔镜肝癌根治术治疗肝癌的临床疗效及对NGF、MMP-13水平的影响

目的:研究腹腔镜肝癌根治术治疗肝癌的临床疗效及对神经生长因子(nerve growth factor,NGF)、基质金属蛋白酶-13(matrix metalloproteinase-13,MMP-13)水平的影响。方法:选取2012年1月至2016年12月我院收治的原发性肝癌患者65例,分别采用开腹肝癌切除术(对照组)和腹腔镜肝癌根治术(观察组),分析两组患者治疗后的临床效果。结果:观察组患者手术时间、排气时间、拔管时间、绝对卧床时间、住院时间均短于对照组;术后3 d时,观察组患者MMP-13、ICAM-1、NGF、PⅢP、PCT水平低于对照组;术后1个月,观察组患者肝功能指标水平低于对照组,差异有统计学意义(P <0. 05)。随访1年后,观察组患者复发率和转移率分别为15. 15%、3. 03%;对照组分别为28. 13%、12. 50%;观察组患者复发率和转移率低于对照组,但组间比较无统计学差异(P> 0. 05)。结论:腹腔镜肝癌根治术较开腹肝癌切除术治疗肝癌更有利于促进肝功能的恢复,可降低MMP-13及NGF水平,且恢复快,住院时间短,但复发率和转移率比较,无明显差异。

Clinical efficacy of laparoscopic radical hepatectomy for hepatocellular carcinoma and its effect on NGF and MMP-13 level

Objective:To study the clinical efficacy of laparoscopic radical hepatectomy for hepatocellular carcinoma and its effect on NGF and MMP-13 level.Methods:From January 2012 to December 2016,65 patients with primary liver cancer in our hospital were treated with open hepatectomy (control group) and laparoscopic radical hepatectomy (observation group).Results:In the observation group,the operation time,the exhaust time,the extubation time,the absolute bed time and the time of hospitalization were shorter than those of the control group.After 3 d,MMP-13,ICAM-1,NGF,PⅢP,and the PCT level in the observation group were lower than that of the control group.The level of liver function index in the observation group was lower than that of the control group at 1 month after the operation,and the difference was statistically significant (P＜0.05).With after one year's visit,the recurrence rate and metastasis rate of the patients in the observation group were 15.15% and 3.03%,and that in the control group were 28.13% and 12.50%,respectively.The recurrence rate and the metastasis rate in the observation group were lower than those in the control group,but there was no statistical difference between the two groups (P＞0.05).Conclusion:Laparoscopic radical resection of liver cancer is more beneficial to promote the recovery of liver function than open hepatectomy.It can reduce the level of MMP-13 and NGF.The recovery is faster and the hospitalization time is short.However,there is no significant difference between the recurrence rate and metastasis rate.