金黄色葡萄球菌VII型分泌系统研究进展

细菌分泌系统是细菌依赖分泌通路进行蛋白质的跨胞浆膜转运系统,该分泌系统中存在的蛋白或蛋白性质的毒力因子与细菌的生存、繁殖和扩散紧密相关。已发现的几种分泌系统中,VII型分泌系统主要存在于革兰氏阳性菌中,其不仅与细菌的生长和致病性密切相关,而且可能在细菌毒力分泌方面发挥关键作用。本文将对金黄色葡萄球菌VII型分泌系统类型、分泌底物结构、对金黄色葡萄球菌的毒力调控机制等方面进行论述。

Research progress on the secretory system of Staphylococcus aureus type VII

The bacterial secretion system is a bacterial-dependent secretory pathway for the transmembrane membrane transport system of proteins. The protein or protein-like virulence factors in the secretory system are closely related to the survival, reproduction and spread of bacteria. Among the several secretory systems that have been discovered, the type VII secretion system is mainly found in Gram-positive bacteria, which is not only closely related to bacterial growth and pathogenicity, but also potentially plays a key role in bacterial virulence secretion. This article will discuss the types of secretory system of Staphylococcus aureus type VII, the structure of secretory substrate, and the virulence regulation mechanism of S.aureus.