| 食管鳞癌组织中RASSF1A和FGF3基因的表达及其意义 |
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| 引用本文： | 卜晓红,蒲红伟,陈晓,沈庆林.食管鳞癌组织中RASSF1A和FGF3基因的表达及其意义[J].河北职工医学院学报,2010,27(1):11-14. |
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| 作者姓名： | 卜晓红 蒲红伟 陈晓 沈庆林 |
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| 作者单位： | 新疆医科大学,病理学教研室,新疆,乌鲁木齐,830011 |
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| 基金项目： | 新疆地方病分子生物学重点实验室专项资金 |
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| 摘 要： | 目的研究食管鳞癌组织中RASSF1A和FGF3基因的表达及其意义。方法采用免疫组织化学Envision二步法检测RASSF1A和FGF3蛋白在80例食管鳞癌及20例食管正常黏膜组织中的表达情况。结果食管鳞癌组织中RASSF1A阳性表达率81.25%,食管正常黏膜组织阳性表达率95.0%,差异有统计学意义（P〈0.01）;食管鳞癌组织中FGF3阳性表达率93.8%,正常粘膜组织阳性表达率50.0%,差异有统计学意义（P〈0.01）。RASSF1A低表达与食管鳞癌病理分期及食管鳞癌浸润深度相关（P〈0.01）;FGF3高表达与食管鳞癌病理分级密切相关（P〈0.05）,并与淋巴结转移、食管鳞癌浸润深度相关（P〈0.05）;两者表达皆与食管鳞癌患者的民族、性别分型无关（P〉0.05）。RASSF1A与FGF3表达呈负相关性,r=-0.419,P〈0.01。结论RASSF1A和FGF3可以成为判断食管鳞癌恶性程度和预后的检测指标。
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| 关 键 词： | 食管鳞癌 RAS效应蛋白1A 成纤维细胞生长因子3 |
Expression and its significance of RASSF1A and FGF3 in esophageal carcinoma |
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| Bu Xiaohong,Pu Hongwei,Chen Xiao,et al..Expression and its significance of RASSF1A and FGF3 in esophageal carcinoma[J].Journal of Hebei Medical College for Continuing Education,2010,27(1):11-14. |
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| Authors: | Bu Xiaohong Pu Hongwei Chen Xiao |
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| Institution: | Bu Xiaohong,Pu Hongwei,Chen Xiao,et al.(Department of Pathology,Xinjiang Medical University,Urumqi 830011) |
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| Abstract: | Objective To study the expression and its significance of RASSF1A and FGF3 in esophageal carcinoma.Methods The expression of RASSF1A and FGF3 in 80 cases with esophageal squamous cell carcinoma and 20 cases of normal esophageal tissues were determined with immunohistochemistry.Results The positive rate of RASSF1A of esophageal carcinoma and normal tissues were 81.25% and 95.0% respectively.The positive rate of RASSF1A was significantly lower than that in normal esophageal tissues (P<0.01).The positive rate ... |
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| Keywords: | esophageal carcinoma RASSF1A FGF3 |
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