δ-氨基乙酰丙酸脱水酶基因多态性与血铅和锌原卟啉的关系

目的　探讨δ 氨基乙酰丙酸脱水酶 (ALAD)基因多态性与血铅和锌原卟啉之间的关系。方法　采样分析 370名严重铅污染区儿童的血铅、锌原卟啉和ALAD基因型。结果　ALAD1 2 / 2 2 基因型的血铅水平 (2 6 2 1± 0 5 6 1) μmol/L高于ALAD1 1基因型 (2 36 0± 0 5 96 ) μmol/L ;而锌原卟啉水平也增高 ,前者 (13 0 7± 9 38) μmol/L ,后者 (9 90± 6 30 ) μmol/L。 结论　在同样的高铅暴露条件下 ,ALAD1 2 / 2 2 基因型可影响儿童体内铅负荷水平以及铅所致血液毒性效应

Relationship between delta-aminolevulinic acid dehydratase gene polymorphism and blood levels of lead and zinc protoporphyrin in children exposed to lead

OBJECTIVE: To explore the associations of polymorphism of delta-aminolevulinic acid dehydratase (ALAD) gene with blood levels of lead and zinc protoporphyrin (ZPP). METHODS: Blood samples were collected from 370 children exposed to a higher level environmental lead and their blood levels of lead and ZPP, and ALAD genotype were examined. Exposure to lead condition, such as parents' lead exposure and sites of lead source around their residence, and age and sex were matched in ALAD1-1 and ALAD1-2/2-2 subgroups. RESULTS: Blood lead level was higher in the ALAD1-2/2-2 subgroup than that in the ALAD1-1 children [(2.621 +/- 0.561) mumol/L vs (2.360 +/- 0.596) mumol/L, P = 0.04)]. Blood ZPP level was also higher in with ALAD1-2/2-2 subgroup than that in the ALAD1-1 genotype [(13.07 +/- 9.38) mumol/L vs (9.90 +/- 6.30) mumol/L), P = 0.02)]. CONCLUSION: The results suggest that the ALAD1-2/2-2 genotype may influence the body burden and blood toxicity of lead in high lead exposed children.