高血压患者血脂紊乱与颈动脉重构相关性的探讨

目的　探讨血脂代谢紊乱与颈动脉重构的关系。方法　入选14 2例,其中正常血压组4 0例,高血压血脂正常者5 2例,高血压伴血脂紊乱者5 0例,通过颈动脉超声测定颈动脉内膜-中膜厚度(intima-mediathickness,IMT)和舒张末期内径(end -diastolicdiameter,Dd) ,探讨低密度脂蛋白胆固醇(LDL -C)、高密度脂蛋白胆固醇(HDL -C)与IMT和Dd 的关系。结果　高血压组IMT及Dd 明显高于正常血压组,高血压伴血脂紊乱组IMT及Dd 高于高血压血脂正常组。LDL -C与颈动脉IMT(R =0 .312 ,P <0 .0 0 1)、Dd(R =0 .32 6 ,P <0 .0 0 1)呈正相关,HDL -C与颈动脉IMT及Dd无明显相关。结论　血脂代谢紊乱尤其LDL -C升高可促进颈动脉重构,伴有高血压血脂紊乱者尤重。

Association of dyslipidmia and carotid artery remodelling in hypertensive patients

Objective To investigate the relation between the dyslipidmia and carotid artery remodling in hypertension. Methods The intima-media thickness (IMT) and end-diastolic diameter (D d) were measured by high resolusion B-mode ultrasound in 142 subjects. The studied population were divided into three groups: group 1,40 normotention subjects;group 2,52 hypertensive subjects without dyslipidmia;group 3,50 hypertensive subjects with dyslipidmia. Results The IMT and D d of hypertension were higher than the normal subjects. The IMT and D d of hypertension with dyslipidmia were higher than the subjects without dyslipidmia. LDL-C had positive correlation with IMT (R=0.312,P<0.001) and D d (R=0.326,P<0.001) of carotid artery,and HDL-C had not correlation with IMT and D d of carotid artery. Conslusions Dyslipidmia especial the rise of LDL-C can promote the remodeling of carotid artery.