补气活血中药对肾缺血再灌注损伤模型大鼠的保护作用研究

目的探讨补气活血中药对肾缺血再灌注损伤模型大鼠的保护作用。方法将大鼠随机分为对照组、模型组和用药组(补气活血中药),用药组预防给药7d;建立肾缺血再灌注损伤模型。比较各组大鼠血清和肾组织中补体C3和一氧化氮(NO)的含量及肾组织病理变化。结果模型组血清和肾组织中补体C3和NO含量升高,肾组织出现明显病理变化;与模型组比较,用药组血清和肾组织中补体C3和NO含量下降,肾组织病理变化明显改善。结论补气活血中药对肾缺血再灌注损伤模型大鼠具有保护作用。

Study on the Protective Effect of Traditional Chinese Medicine that Invigorating Vital Energy and Promoting Blood Flow on Model of Renal Ischemical Reperfusion Injury of Rats

OBJECTIVE:Approach to the protective effect of traditional Chinese medicine that invigorating vital energy and promoting blood flow on model of renal ischemical reperfusion injury of rats.METHODS:The rats were divided into control group,model group and medication group(traditional Chinese medicine that invigorating vital energy and promoting blood flow),the medication group were given prevention administration for7days;model of renal ischemical reperfusion injury of rats were established.The contents of complement C3and nitric oxide(NO)in serum and renal tissue and the pathological changes of renal tissues in each group were compared.RESULTS:Levels of complement C3and NO in serum and renal tissue were increased in the model group and there were obvious pathological changes in renal tissues;compared with the model group,there was a decrease in the contents of complement C3and NO in serum and renal tissues and there was an obvious improvement in the renal tissues in the medication group.CONCLUSION:The traditional Chinese medicine that invigorating vital energy and promoting blood flow has a protective effect on the model rats with renal ischemical reperfusion injury.