| 原发性肝癌患者介入治疗前后血清GPC3水平检测的临床价值 |
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| 引用本文： | 黄芳,李华东,王高雄.原发性肝癌患者介入治疗前后血清GPC3水平检测的临床价值[J].中国现代普通外科进展,2009,12(3). |
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| 作者姓名： | 黄芳 李华东 王高雄 |
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| 作者单位： | 福建医科大学附属第二医院,放射科,福建,泉州,362000 |
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| 摘 要： | 目的:了解原发性肝癌(hepatocellar carcinoma,HCC)介入治疗前后GPC3的浓度变化和临床价值.方法:采用ELISA法检测HCC、肝硬化、正常人血清GPC3浓度.结果:51例HCC患者、16例肝硬化患者、正常人组血清GPC3浓度分别为(3 939.72±2 801.92)、(619.08±542.80)和(534.24±500.20)pg/mL,前者与后二者比较差异有统计学意义(P<0.05),但其表达与血清甲胎蛋白(alpha-fetoprotein,AFP)无显著相关性;32例HCC患者介入治疗后高转移复发倾向组血清GPC3浓度为(4 418.00±3941.96)pg/mL,低转移复发倾向组血清GPC3浓度为(534.44±910.56)pg/mL,二者比较差异有统计学意义(P<0.05);缓解组、稳定组、恶化组血清GPC3浓度分别为(571.64±288.72)、(2 521.76±2340.76)、(4 812.84 4-1 858.64)pg/mL,3组两两比较差异均有统计学意义(P<0.05).结论:GPC3在HCC患者血清中的检出率高,特异性强,其表达与AFP无相关性,联合应用AFP及GPC3可提高诊断的灵敏度.GPC3与肿瘤复发转移、治疗效果有关.
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| 关 键 词： | 癌 肝细胞 介入治疗 |
Clinical significance of glypican-3 serum levels in patients with hepatocellar carcinoma of interventional therapy |
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| HUANG Fang,LI Hua-dong,WANG Gao-xiong.Clinical significance of glypican-3 serum levels in patients with hepatocellar carcinoma of interventional therapy[J].Chinese Journal of Current Advances in General Surgery,2009,12(3). |
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| Authors: | HUANG Fang LI Hua-dong WANG Gao-xiong |
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| Institution: | Quanzhou 362000;China |
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| Abstract: | Objective:To study the clinical significance of serum glypican-3 in patients with hepatocellar carcinoma who underwent interventional therapy.Methods:Serum levls of glypican-3 were detected with ELISA in patients with hepatocellar carcinoma,cirrhosis and normal people.Results:Serum levels of glypican-3 in patients with hepatocellar carcinoma(52 cases)were significantly higher than those with cirrhosis(16 cases)or healthy group(30 cases)(P<0.05).But with the serum AFP there was no significant correlation.GPC... |
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| Keywords: | GPC3 AFP |
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