头孢吡肟与其他5种广谱β内酰胺类抗生素抗菌活性的比较

目的：比较头孢吡肟与其他５种广谱β内酰胺类抗生素的抗菌活性。方法：用Ｅ－ｔｅｓｔ方法测定头孢吡肟及其他５种抗生素对１００株细菌的最低抑菌浓度。结果：所测受测菌对６种抗生素的总敏感性依次为：亚胺培南－西司他丁 ９４％、头孢吡肟８５％、头孢哌酮－舒巴坦 ７８％、头孢他啶 ７７％、头孢曲松 ６５％、哌拉西林 ４８％。头孢吡肟对苯唑西林敏感的葡萄球菌具有很强的抗菌活性,对肠杆菌科细菌的抗菌活性强于第３代头孢菌素,对绿脓杆菌的抗菌活性与头孢他啶相似。结论：头孢吡肟对革兰阴性杆菌的抗菌活性比第３代头孢菌素强,对革兰阳性球菌也加强了抗菌覆盖。

Evaluation study on antimicrobial activity of cefepime compared to other five broad-spectrum beta-lactam antibiotics

AIM: To compare the antimicrobial activity of cefepime with other five broad-spectrum beta-lactams. METHODS: EmPloyed E-test method to determine the minimum inhibiting concentration (MIC) of antibiotics against 100 strains bacteria. RESULTS: Among the six antimicrobial agents tested, imipenem and cefepime were the most active against all isolates tested. The rank order of susceptibility of the six agents was imipenem (94 % ), cefepime (85% ), cefoperazone /sulbactam (7 8 % ), ceftazidime (77% ), ceftriaxone (65 % ), piperacillin (48 % ). It was showed that cefepime had been very active against oxacillin-susceptible staphylococci. The activity of cefepime was stronger than that of" the third generation" cephalosporins against Enterobacteriaceae, and similar to ceftazidime against Pseudomonas aeruginosa. CONCLUSION: The antimicrobial activity of cefepime is stronger than that of" the third generating" cephalosporins not only against gram-negative bacilli but also against gram-positive cocci.