Perinuclear anti-neutrophil cytoplasmic antibody in systemic lupus erythematosus indicates more severe condition |
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| Affiliation: | 1. Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey;2. Department of Cardiology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey;3. Department of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey;4. Department of Public Health, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey;1. Department of Neurology, Clinical Medical College, Yangzhou University, 98 Nantong West Road, Yangzhou 225001, China;2. Department of Endocrinology, Clinical Medical College, Yangzhou University, 98 Nantong West Road, Yangzhou 225001, China;3. Department of Center of Health Management, Clinical Medical College, Yangzhou University, 98 Nantong West Road, Yangzhou 225001, China;4. Department of Biobank, Clinical Medical College, Yangzhou University, 98 Nantong West Road, Yangzhou 225001, China;5. Department of Ultrasonography, Clinical Medical College, Yangzhou University, 98 Nantong West Road, Yangzhou 225001, China;1. The Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China;2. The Department of Medical Administration, The First Affiliated Hospital of Harbin Medical University, Harbin, China;1. Clinical Laboratory, Biochemistry Department, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí I3PT, Sabadell, Spain;2. Paediatrics Department, Parc Taulí Hospital Universitari, Sabadell, Spain;1. Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States;2. ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, United States |
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| Abstract: | ObjectiveTo investigate the clinical significance of perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) in patients with systemic lupus erythematosus (SLE).MethodsThis retrospective study included 120 SLE patients. All patients were divided into group p-ANCA+ and group p-ANCA−. Demographic characteristics, clinical symptoms, autoantibodies, laboratory tests and renal pathology were compared between these two groups.ResultsAmong 120 patients, 45 (37.5%) patients were p-ANCA+ and 75 (62.5%) patients were p-ANCA−. The occurrence of lupus nephritis was significantly higher in group p-ANCA+ (P = 0.046). For autoantibodies, the occurrences of anti-dsDNA, anti-nucleosome and anti-histone were significantly higher in group p-ANCA+ (P < 0.001, P = 0.004 and P = 0.006, respectively). Titers of anti-dsDNA antibody, erythrocyte sedimentation rate (ESR), serum beta-2-microglobulin (β2-MG) and systemic lupus erythematosus disease activity index (SLEDAI) were higher in group p-ANCA+ (P < 0.001, P = 0.021, P < 0.001 and P = 0.005, respectively), while albumin was significantly lower than p-ANCA− group (P = 0.012). There were no differences in the classification of lupus nephritis, activity index and chronicity index. p-ANCA correlated with lupus nephritis, anti-dsDNA antibody, anti-nucleosome antibody and anti-histone antibody, and also disease activity markers, such as titers of anti-dsDNA antibody, ESR, albumin, serum β2-MG and SLEDAI.ConclusionThe appearance of p-ANCA in SLE indicated high probability of lupus nephritis and more severe condition. |
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| Keywords: | Systemic lupus erythematosus Perinuclear anti-neutrophil cytoplasmic antibody Clinical characteristics Disease activity Lupus nephritis |
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