Clinical laboratory characteristics of patients with obstructive jaundice accompanied by dyslipidemia |
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| Affiliation: | 1. Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China;2. MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, China;1. Clinical Laboratory, Hospital Universitari de Sant Joan d’Alacant, Sant Joan d’Alacant, Spain;2. Department of Clinical Medicine, Universidad Miguel Hernández, Elche, Spain;3. Department of Biochemistry and Molecular Pathology, Universidad Miguel Hernandez, Elche, Spain;4. CIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;5. Department of Radiology, University of Missouri, Columbia, MO, USA;1. Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Goettingen, Germany;2. Kogod Center on Aging and Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA;3. Trauma & Orthopaedics, Southmead Hospital, Bristol BS10 5NB, United Kingdom;1. Department of Pathology, University of Utah, Salt Lake City, UT, USA;2. ARUP Laboratories, Salt Lake City, UT, USA;3. ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA |
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| Abstract: | BackgroundAbnormal lipid metabolism manifests as hypercholesterolemia in patients with obstructive jaundice due to lipoprotein X (LpX). Our aim was to explore the clinical laboratory characteristics of patients with obstructive jaundice accompanied by dyslipidemia in a large number of samples.MethodsA total of 665 patients with obstructive jaundice were included and categorized into two groups (with/without dyslipidemia) based on the ratio of the sum of HDL-c and LDL-c to total cholesterol [(HDL-c + LDL-c)/TC] with a cut-off value of 0.695. Laboratory liver, kidney, and blood lipid parameters were determined. Cholesterol composition assessment was performed by ultracentrifugation and high-performance liquid chromatography (UC-HPLC), and serum protein profiles were analyzed by capillary electrophoresis.ResultsLiver function in patients with obstructive jaundice accompanied by dyslipidemia was more aggravated than that in patients with simple obstructive jaundice (P < 0.05). The (HDL-c + LDL-c)/TC ratio was negatively correlated with bilirubin levels (P < 0.05). In addition, the difference in ApoB/LDL-c ratios was statistically significant between the obstructive jaundice accompanied by dyslipidemia group and healthy control group (P < 0.05). The LDL-c concentration determined by the UC-HPLC method was more than five times that determined by the enzymatic method (P < 0.05). Bisalbuminemia was found in 43 of 60 patients with obstructive jaundice accompanied by hypercholesterolemia.ConclusionsIn patients with obstructive jaundice, the decreased (HDL-c + LDL-c)/TC ratio may be a novel marker to identify dyslipidemia secondary to LpX. The decreased ratio was associated with poor liver function and indicated disease progression. |
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| Keywords: | Obstructive jaundice Dyslipidemia Lipoprotein X (HDL-c + LDL-c)/TC ratio |
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