Data mining: Biological and temporal factors associated with blood parathyroid hormone,vitamin D,and calcium concentrations in the Southwestern Chinese population |
| |
| Affiliation: | 1. Department of Clinical Laboratory Sciences, College of Medical Applied Sciences, University of Hafr Al Batin, Hafr Al Batin, Saudi Arabia;2. Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, Egypt;3. Chemistry Department, Faculty of Science, Damietta University, Damietta 34517, Egypt;4. Department of Laboratories, Immunology Lab, Mansoura University Children’s Hospital, Mansoura, Egypt;1. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;2. School of Computing and Information, University of Pittsburgh, Pittsburgh, PA, USA;3. Department of Pathology, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA;4. Department of Pediatrics, UPMC Children''s Hospital of Pittsburgh, Pittsburgh PA, USA;5. University of Pittsburgh School of Medicine, Pittsburgh PA, USA;1. Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland;2. GREAT Network;3. Critical Care Research Group, The Prince Charles Hospital, Brisbane, and the University of Queensland, Brisbane, Australia;4. Division of Internal Medicine, University Hospital Basel, University of Basel, Switzerland;5. Department of Cardiac Surgery, University Hospital Basel, University of Basel, Switzerland;6. Division of Cardiology, Medical University of South Carolina, Charleston, SC, United States;7. Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain;8. Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain;10. Emergency Department, Kantonsspital Liestal, Switzerland;11. Emergency Department, University Hospital Zurich, Zurich, Switzerland;12. Emergency Department, Kantonsspital Luzern, Switzerland;1. The Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China;2. The Department of Medical Administration, The First Affiliated Hospital of Harbin Medical University, Harbin, China;1. Clinical Laboratory, Biochemistry Department, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí I3PT, Sabadell, Spain;2. Paediatrics Department, Parc Taulí Hospital Universitari, Sabadell, Spain |
| |
| Abstract: | BackgroundParathyroid hormone (PTH) and vitamin D plays a major role in calcium (Ca) homeostasis and bone turnover. The purpose of this study was to assess which factors (sex, age, time of blood sampling, season of the year, temperature and sunshine hours (SHH)) had the greatest impact on plasma PTH, 25-OH-VitD, and Ca levels, and then whether these effects were clinically acceptable in a large number of Southwestern Chinese subjects.MethodThe data was from West China Hospital Health Examination Center, Sichuan University from April 1, 2018 to June 30, 2019. A total of 18,664 physical examination subjects were included. PTH and 25-OH-VitD were measured by a Roche Cobas e 601, and Ca was measured by a Roche Cobas 8000. Linear regression models were used to assess correlations between PTH, 25-OH-VitD, Ca and the above factors.ResultsThe concentrations of serum PTH in females were significantly higher than those in males, while the 25-OH-VitD and Ca were opposite. The concentration of PTH in data collection decreased in summer and increased in spring. The concentration of 25-OH-VitD decreases in spring and increases in autumn. PTH concentrations were negatively correlated with last month temperature and SHH, while 25-OH-VitD were opposite. Linear regression showed that season may be the main factor affecting serum PTH and 25-OH-VitD levels, and these effects were not clinically acceptable.ConclusionIn order to avoid influencing clinicians' investigation of suspected hyperparathyroidism and hypovitaminosis, reference intervals for PTH, 25-OH-VitD, and Ca should be established, taking into account sex, age and the season. |
| |
| Keywords: | Parathyroid hormone Vitamin D Seasonal variation Temperature Sunshine hours |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
