阿莫西林／克拉维酸钾分散片小鼠体内抗菌作用研究

目的观察阿莫西林／克拉维酸钾的新剂型-分散片对产β-内酰胺酶的金黄色葡萄球菌和大肠杆菌感染小鼠的保护效果。方法以Bliss法计算各感染小鼠的药物半数有效量（EDS0）值和95％可信限。结果分散片对金黄色葡萄球菌感染小鼠的ED50值和95％可信限为3．7486（3．3967-4．205）mg／kg；对大肠杆菌感染小鼠的ED50值和95％可信限为4．6629（4．0373—5．3855）mg／kg。结论阿莫西林／克拉维酸钾分散片口服给药对产β-内酰胺酶的金黄色葡萄球菌和大肠杆菌感染小鼠具有明显疗效。

The antibiotic effect in vivo research of amoxicillin-clavulanic acid dispersible tablets

Objective To observe the protection effect of amoxieillin-elavulanie acid dispersible tablets on mice infected by the S. anreus and E, coli producoingβ-lactamase. Methods ED50 value and 95% confidence interval of infected mice by Bliss were measured. Result The ED50 value of amoxicillin-clavulanic acid dispersible tablets against mice infected by S. aureus and E. coli were 3. 7486 mg/kg（ 95% confidence interval ,3. 3967 -4. 205 mg/kg ）and 4.6629 mg/kg（95% confidence interval ,4. 0373 -5. 3855 mg/kg）, respectively. Conehlusion Oral administration of amoxicillin-clavuianic acid dispersible tablets has obviously protective effect to the mice infected by the S. aureus and E. coli that preduce β-lactamase.