缺血修饰性清蛋白的临床应用研究

目的探讨缺血修饰性清蛋白（IMA）在急性冠状动脉综合征（ACS）早期诊断价值。方法将89例ACS患者分别于胸痛发作2、4、6、12h及24h采血检测IMA、肌钙蛋白I（cTnI）和肌酸激酶MB同功酶（CK—MB）。其中急性心肌梗死41例，心绞痛48例。分析IMA对ACS的诊断价值。结果ACS患者IMA水平于胸痛发作2h明显增高，4h达到高峰，6h后降至正常。而cTnI，CK—MB在胸痛发作4h开始增高，6h明显增高，以后逐步递增至24h。在心绞痛、心肌梗死中，IMA水平升高以心绞痛最明显（P〈0．05）。结论IMA是诊断ACS早期敏感指标，是诊断心肌缺血的生化标志物。

Clinical Application of Ischemia Modified Albumin

Objective To explore the ischemic modified albumin(IMA)in patients with acute coronary syndrome(ACS)early diagnaontic value.Methods In 89 cases of patients with ACS,present the onset of chest pain,2 h、6 h、12 h and 24 h blood test,IMA,cTnI and CK-MB.41 cases of acute myocardial infarction(AMI),angina pectoris 48 cases.IMA analysis for the diagnostic value of Acs.Results Patients with ACS、IMA level in onset of chest pain,2 h significantly higher peak,reched peak at 4 hours,returned tonormal at 6 hours.Instead CK-MB、cTnI 4 h began in the onset of chest pain increased significantly increased after 6 h,gradually increasing,myocandial infarction,IMA levels with angina in the most obvious(P＜0.05).Conclusion Early diagnosis of ACS IMA is sensitive indicators,the biochemical markers diagnosis of myocordial ischemia.