自体骨髓促进引导性骨再生

目的　研究自体骨髓增强引导性骨再生 (GBR)修复骨缺损的能力。方法　 18只兔分为 5组 ,每组 3只 (第 5组 6只 ) ,造成双桡骨干 10 mm骨缺损 ,以硅胶管桥接骨断端 ,实验组于 0、2和 4周分别在硅胶管内注射自体骨髓 0 .3ml;对照组于相同时间点注射等量外周静脉血。在不同时间内作 X线片、大体、组织学观察及生化检测。结果　实验组成骨活跃 ,10周骨缺损完全修复 ,对照组各时间点均较实验组差 ,10周时仍无 1只兔骨性愈合。术后 2、4周实验组钙及碱性磷酸酶含量明显高于对照组。结论　自体骨髓可明显增强 GBR修复骨缺损的能力

EXPERIMENTAL STUDY ON STIMULATION OF GUIDED BONE REGENERATION BY AUTOGENOUS BONE MARROW

Objective To study the effect of autogenous bone marrow on guided bone regeneration (GBR), and evaluate the repairing ability of GBR in bone defect with autogenous bone marrow. Methods Ten mm segmental defects were produced in both radii of 18 rabbits. The defect was bridged with a silicon tube. Autogenous bone marrow was injected into the tube on the experimental group at 0, 2, 4 weeks after operation, and peripheral blood into the control group at the same time. The X ray, gross, histological and biochemical examinations were observed in various times. Results The new bone formation of experimental group was prior to that of control group; calcium and alkaline phosphatase of experimental group were higher than those of control group. The experimental group had all been healed at the tenth week, but no one healed in control group. Conclusion It can be conclude that autogenous bone marrow can stimulate bone formation and facilitate GBR in bone defect.