Interaction of bis-β-chlorethylamine estrogen derivatives with human ovarian adenocarcinoma cells |
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| Authors: | A V Semeikin V M Rzheznikov O N Minailova Ya V Dobrynin E E Mayatskaya |
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| Institution: | (1) Department of Molecular Pharmacology and Radiobiology, Russian State Medical University, Moscow;(2) Endocrinology Research Center, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Antiproliferative effect of bis-β-chlorethylamine estrogen derivatives on human ovarian adenocarcinoma CaOV cells depends
on the dose of the drug. In concentrations of 10−5 and 5×10−6 M they inhibit, while in a dose of 5×10−7 M stimulate cell proliferation. It is assumed that CaOV cells express estradiol receptors. The interaction of these cytostatics
with estrogen-binding sites on CaOV cells is demonstrated.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 3, pp. 302–304, March, 1999 |
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| Keywords: | bis-β -chlorethylamines estrogens cell culture estradiol receptors |
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