药学监护和电话随访对长期使用糖皮质激素哮喘患儿治疗依从性及疗效的影响

目的探讨药学监护和电话随访对长期使用糖皮质激素哮喘患儿治疗依从性及疗效的影响。方法将60例接受糖皮质激素吸入治疗的哮喘患儿分为观察组40例和对照组20例,2组患儿均给予糖皮质激素吸入治疗,观察组患儿在治疗过程中给予电话随访和药学监护,对照组患儿仅实施常规指导,2组患儿均进行为期1 a的观察,对2组患儿血清肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、IL-8、IL-10水平、服药依从性及治疗效果进行比较。结果观察组患儿治疗依从性和总有效率均显著高于对照组(P<0.01)。2组患儿治疗前血清TNF-α、IL-6、IL-8和IL-10水平比较差异均无统计学意义(P>0.05);治疗3、6、12个月后,2组患儿血清TNF-α、IL-6、IL-8和IL-10水平比较差异均有统计学意义(P<0.05);与治疗前比较,治疗3、6、12个月后2组患儿血清TNF-α、IL-6和IL-8水平显著降低(P<0.05),IL-10水平显著升高(P<0.05);与治疗3个月时比较,观察组患儿治疗6、12个月后血清TNF-α、IL-6和IL-8水平显著降低,IL-10水平显著升高,差异均有统计学意义(P<0.05)。对照组患儿治疗6、12个月后血清TNF-α、IL-6、IL-8和IL-10水平与治疗3个月时比较差异均无统计学意义(P>0.05)。结论对长期吸入糖皮质激素治疗的哮喘患儿进行定期电话随访和药学监护,可以明显提高患儿治疗依从性,改善患儿血清炎性因子水平,提高疗效。

Influence of pharmaceutical care and telephone follow-up on the treatment compliance and curative effect of long-term use of glucocorticoid in children with asthma

Objective To investigate the influence of pharmaceutical care and telephone follow-up on the treatment compliance and curative effect of long-term use of glucocorticoid in children with asthma.Methods Sixty asthma children treated with glucocorticoid inhalation were divided into observation group(n=40)and control group(n=20),the children in observation group were performed with pharmaceutical care and telephone follow-up during the treatment,the children in control group only received the routine guidance.All children were observed for one year,the levels of tumor necrosis factor-α(TNF-α),interleukin(IL)-6,IL-8,IL-10,the treatment compliance and curative effect were compared between the two groups.Results The treatment compliance and curative effect in observation group were significantly higher than those in control group(P<0.01).Before treatment,there was no significant difference in the levels of TNF-α,IL-6,IL-8 and IL-10 between the two groups(P>0.05).After treatment of 3,6,12 months,there were significant differences in the levels of TNF-α,IL-6,IL-8 and IL-10 between the two groups(P<0.05).In the two groups,the levels of TNF-α,IL-6 and IL-8 after treatment of 3,6,12 months were significantly lower than those before treatment(P<0.05);the level of IL-10 after treatment of 3,6,12 months was significantly higher than that before treatment(P<0.05).In observation group,the levels of TNF-α,IL-6 and IL-8 after treatment of 6,12 months were significantly lower than those after treatment of 3 months(P<0.05);the level of IL-10 after treatment of 6,12 months was significantly higher than that after treatment of 3 months(P<0.05).There was no significant difference in the level of TNF-α,IL-6,IL-8 and IL-10 between after treatment of 6,12 months and after treatment of 3 months in control group(P>0.05).Conclusion Regular telephone follow-up and pharmaceutical care for asthma children with long-term use of glucocoticoids can significantly improve the treatment compliance,the levels of inflammatory factor and the curative effect.