| 离子通道病与遗传性心律失常 |
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| 引用本文： | 丰明俊,储慧民,陈晓敏. 离子通道病与遗传性心律失常[J]. 浙江大学学报(医学版), 2010, 39(1). DOI: 10.3785/j.issn.1008-9292.2010.01.017 |
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| 作者姓名： | 丰明俊 储慧民 陈晓敏 |
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| 作者单位： | 宁波大学医学院附属第一医院,浙江,宁波,315010 |
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| 摘 要： | 离子通道病是遗传性心律失常的主要病因,可分为由钠离子通道、钾离子通道和钙离子通道基因变异所致的心律失常综合征.其机理是编码心肌细胞离子通道亚单位的基因变异,导致离子通道功能的变化,进而引起异常的心电活动,临床表现为恶性心律失常.
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| 关 键 词： | 心律失常/遗传学 离子通道 |
Ion channelopathies and inherited arrhythmia |
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| FENG Ming-jun,CHU Hui-min. Ion channelopathies and inherited arrhythmia[J]. Journal of Zhejiang University. Medical sciences, 2010, 39(1). DOI: 10.3785/j.issn.1008-9292.2010.01.017 |
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| Authors: | FENG Ming-jun CHU Hui-min |
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| Affiliation: | FENG Ming-jun,CHU Hui-min(Ninbo First Hospital,Affiliated Medical of Ninbo University,Ninbo 315010,China) |
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| Abstract: | Ion channelopathies are the mainly etiopathogenisis of inherited arrhythmia.Those arrhythmia syndromes are commonly caused by ion channel gene mutation,which can be classified as sodium,potassium and calcium ion channel mutation.Changes in the genes encoding for cardiac ion channel subunits produce modification in the function of the channels,and cause the dysfunctions of cardiac electrical activity;and the clinical manifestation is malignant arrhythmia. |
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| Keywords: | Arrhythmia/genet Ion channels |
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