Detection of glial fibrillary acidic protein and neurofilaments in the cerebrospinal fluid of patients with neurocysticercosis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Detection of glial fibrillary acidic protein and neurofilaments in the cerebrospinal fluid of patients with neurocysticercosis

Authors:	J.?Luis?Quintanar author-information" > author-information__contact u-icon-before" > mailto:jlquinta@correo.uaa.mx" title=" jlquinta@correo.uaa.mx" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Luis?Manuel?Franco,Eva?Salinas

Affiliation:	Laboratory of Neurophysiology, Department of Physiology and Pharmacology, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Avenida Universidad 940, C.P. 20100, Aguascalientes, Aguascalientes, México. jlquinta@correo.uaa.mx

Abstract:	Neurocysticercosis (NCC) is an infection caused by Taenia solium larval metacestodes in the central nervous system. The glial fibrillary acidic protein (GFAP) and neurofilaments (NFs) can be used as markers of glial and neuronal damage, respectively. We studied the GFAP and NFs of 68, 160 and 200 kDa in the cerebrospinal fluid (CSF) of patients with NCC by Western blotting. Our results showed that patients with NCC had significantly elevated GFAP levels in the CSF compared with the control, whereas NFs of 68, 160 and 200 kDa were not detected in the CFS of NCC patients. We concluded that GFAP could be used as a marker of glial damage in the CFS of NCC patients.

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