| 重症肌无力被动转移动物模型的研究 |
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| 引用本文： | 高波廷,李保华,杨明山,卜碧涛,徐金枝.重症肌无力被动转移动物模型的研究[J].中国临床神经科学,2001,9(2):130-132. |
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| 作者姓名： | 高波廷 李保华 杨明山 卜碧涛 徐金枝 |
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| 作者单位： | 同济医科大学附属同济医院神经内科, |
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| 摘 要： | 目的 :探讨血清阳性 (SPMG)和阴性重症肌无力 (SNMG)被动转移动物模型 (P EAMG)的异同。方法 :用ELISA法将重症肌无力 (MG)患者分为SNMG和SPMG两组 ,然后分别用两组患者血清制作P EAMG ,观察两组小鼠的临床表现、电生理及神经肌接头(NMJ)的改变。结果 :SPMG和SNMG组小鼠均表现出明显的肌无力症状 ,低频重复电刺激出现明显衰减反应 ,但SNMG组小鼠肌无力症状较SPMG组明显为轻 ,SPMG和SNMG组小鼠NMJ处棕黄色沉积物明显减少、变细短。结论 :SNMG和SPMG均是自身抗体介导的自身免疫性疾病 ,但两者不完全相同
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| 关 键 词： | 血清阳性重症肌无力 血清阴性重症肌无力 被动转移动物模型 |
| 修稿时间： | 1999年11月11 |
A Study on the Models of Myasthenia Gravis (MG) in Mice |
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| GAO Bo Ting,LI Bao Hua,YANG Ming Shan,et al.A Study on the Models of Myasthenia Gravis (MG) in Mice[J].Chinese Journal of Clinical Neurosciences,2001,9(2):130-132. |
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| Authors: | GAO Bo Ting LI Bao Hua YANG Ming Shan |
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| Institution: | GAO Bo Ting,LI Bao Hua,YANG Ming Shan,et al Department of Neurology,Tongji Hospital,Tongji Medical University,Wuhan 430030 |
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| Abstract: | Aim:To study the differences between seropositive MG(SPMG) and seronegative MG(SNMG) of P EAMG.Methods:SPMG and SNMG were developed while 40 Balb/c mice were intraperitoneally transfered AChRab positive and AChRab negative MG patient sera, respectively. SPMG and SNMG mice were observed in clinical features, low frequency eletrostimulation responses (LFER), and neuromuscular junction (NMJ) AChR changes.Results:Both SPMG and SNMG mice showed markedly myasthenic symptoms, LFER decrement, and motor end plate AChR reduction. But SPMG mice were more serious than SNMG ones in clinical myasthenic symptoms. Conclusion:SPMG and SNMG are similar autoimmune disorders, but there are some differences in the two kinds of MG. |
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| Keywords: | seropositive myasthenia gravis (SPMG) seronegative myasthenia gravis (SNMG) passively transferred experimental autoimmune MG(P EAMG) |
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