CD80 (B7-1) and CD86 (B7-2) genes and genetic susceptibility to coeliac disease. |
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| Authors: | N Woolley P Holopainen C Bourgain K Mustalahti P Collin M M?ki J Partanen |
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| Affiliation: | Department of Tissue Typint, finnish Red Cross Blood Transfusion Service, Helsinki, Finland. |
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| Abstract: | The role of the costimulatory molecules B7-1 (CD80) and B7-2 (CD86) in T-cell activation makes them good candidates for coeliac disease susceptibility genes. We conducted a genetic linkage study of the CD80/86 gene region in the general Finnish population and in a local subisolate. No linkage was found in either population. |
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