Immunosuppressive activity of 15-deoxyspergualin and its effect on skin allografts in rats |
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| Authors: | T Masuda S Mizutani M Iijima H Odai H Suda M Ishizuka T Takeuchi H Umezawa |
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| Affiliation: | Institute for Chemotherapy, Microbial Chemistry Research Foundation, Shizuoka, Japan. |
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| Abstract: | The immunosuppressive activity of spergualin analogues, 15-deoxyspergualin and N-30, is presented. These compounds suppressed antibody formation and establishment of delayed-type hypersensitivity to sheep red blood cells (SRBC) in mice. Among spergualin, 15-deoxyspergualin, and N-30, 15-deoxyspergualin was most effective in suppressing immune responses. It suppressed antibody formation against SRBC by spleen cell cultures in a dose-dependent fashion without reducing cell viability. The spergualins also suppressed the mixed lymphocyte culture reaction. Peritoneal exudate cells taken from mice given immunosuppressive doses of 15-deoxyspergualin were not reduced in their functions measured: Release of lysosomal enzymes and production of superoxide anions. 15-Deoxyspergualin and N-30 were markedly effective in prolonging skin graft in rats. |
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