银屑病和鱼鳞病患者血清必需脂肪酸分析

为了探讨必需脂肪酸与鳞屑性皮肤病的关系，用气相质谱法分析了寻常型银屑病，性联隐性鱼鳞病，寻常型鱼鳞病和正常对照组的血清和血清磷脂脂肪酸的组成，结果：银屑病组Ｃ＾４２０、Ｃ＾４２２、Ｃ＾５２２显著低于正常，而Ｃ＾２１８、Ｃ＾３１８及Ｃ＾３２０明显升高。

Serum essential fatty acid analyses in patients with psoriasis and ichthyosis

In order to investigate the relationship between essential fatty acids (EFAs) and scaling diseases, we detected the constituent of fatty acids in serum and serum phospholipids of psoriasis vulgaris, recessive X linked ichthyosis, ichthyosis vulgaris and normal control The results showed that C 4 20 C 4 22 andC 5 22 of serum EFAs significant decreased and C 2 18 C 3 18 and C 3 20 significant increased in PV group than in normal group ( P < 0 01) Compared with normal group, C 3 20 , C 4 20 , C 4 22 , C 5 22 lower and C 2 18 , C 3 18 higher significantly in 2 ichthyosis groups ( P < 0 01) Further EFAs analyses in serum phospholipid indicated that there were no significant differences in C 2 18 , C 3 18 between 3 patient group and norm al control It suggested that C 2 18 and C 3 18 drived from foods were not deficient, and EFAs especially arachidonic acid deficiency may explained the scaling of corneocyte hyperproliferation Serum C 3 20 increased in PV group but decreased in 2 ichthyosis groups significantly suggested that there were desaturatase abnormality in PV patients and elongatase abnormality in RXLI and IV patients