献血感染丙型肝炎人群转归分析

目的研究献血感染丙型肝炎病毒（HCV）人群16年后的转归。方法对该人群问卷收集一般情况,肝脏B超检查;采集5ml静脉血,进行丙型肝炎病毒抗体、RNA、谷丙转氨酶（ALT）和血清生化指标（透明质酸、Ⅲ型前胶原肽、Ⅳ型胶原）检测。结果162名研究对象尚未出现晚期肝病患者。抗-HCV阳性率95.68%,RNA阳性率77.78%,ALT异常率20.37%。不同急性期症状感染者,16年后抗-HCV阳性率、ALT异常率和RNA阳性率差异无统计学意义。经性别分层分析,女性感染年龄〉40岁抗体较易阴转（χMH^2=8.26,P=0.04）。结论HCV感染16年后,不同急性期症状感染者转归无差异,病毒清除与性别和初始感染年龄有关。

Study on outcome of chronic hepatitis C in plasmapheresis donors

Objective To determine the outcome of blood donors infected with hepatitis C virus(HCV) for 16 years.Methods The symptoms and physical signs of patients were filled in questinnaire.5ml venous blood was collected from each patient.The alanine transaminase(ALT),anti-HCV,HCV RNA and biochemical marker in sera were detected.Results All of 162 patients didn't present severe hepatitis symptom and physical signs.95.68% showed evidence of positive anti-HCV;77.78% showed positive HCV RNA.The abnormal rate of ALT was 20.37% in this cohort.Stratified analysis showed that anti-HCV in serum was easier to change to be negative female of infection age over 40 than other patients.Conclusion Serum conversion may be correlated with female gender and the age of the patient at the onset.The outcome of patients with different symptoms didn't present variance.