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Reversible serotoninergic neurotoxicity ofN-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse striatum studied by neurochemical and immunohistochemical approaches |
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| Authors: | Kenji Hara Ikuo Tohyama Hiroshi Kimura Hidetoshi Fukuda Shigenobu Nakamura Masakuni Kameyama |
| Affiliation: | 1Department of Neurology, Faculty of Medicine, Kyoto University, Kyoto, Japan 2Department of Anatomy, Shiga University of Medical Science, Otsu, Shiga, Japan |
| Abstract: | Effects ofN-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on serotonin (5-HT) were studied in mouse striatum. The 5-HT level was significantly reduced at 1 week after MPTP, though returned at 4 weeks. The level of 5-hydroxyindoleacetic acid (5-HIAA) increased at both 1 and 4 weeks. The ratio of increase in 5-HT induced by pargyline administration was larger in MPTP-pretreated mice than in vehicle-pretreated controls at 1 week, although it was identical in both groups at 4 weeks. The 5-HT immunohistochemical study confirmed the biochemical change of 5-HT. These results suggest that MPTP functionally affects the 5-HT metabolism in mouse striatum. |
| Keywords: | N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Serotonin Mouse Striatum High-performance liquid chromatography (HPLC) Immunohistochemistry |
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