| HPLC测定氯碘羟喹的含量及有关物质 |
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| 引用本文： | 张西如,高燕霞,姜建国,孙婷.HPLC测定氯碘羟喹的含量及有关物质[J].中国现代应用药学,2009,26(10):844-846. |
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| 作者姓名： | 张西如 高燕霞 姜建国 孙婷 |
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| 作者单位： | 河北省药品检验所，石家庄 050011 |
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| 摘 要： | 目的建立氯碘羟喹的含量及有关物质的HPLC测定方法。方法采用C8柱，以乙二胺四醋酸二钠缓冲液-甲醇（35：65）为流动相；流速1．0mL．min^-1；检测波长为254nm。结果氯碘羟喹的线性范围为3～60ug．mL^-1（r=0．9999），平均回收率为99．8％，RSD为0．13％（n=9）。结论方法简便、准确，专属性强，可作为产品的含量和有关物质的检测。
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| 关 键 词： | 氯碘羟喹 高效液相色谱法 有关物质 |
| 收稿时间： | 1/1/1900 12:00:00 AM |
Determination of Clioquinol and Its Related Substances by HPLC |
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| ZHANG Xiru,GAO Yanxi,JIANG Jianguo,SUN Ting.Determination of Clioquinol and Its Related Substances by HPLC[J].The Chinese Journal of Modern Applied Pharmacy,2009,26(10):844-846. |
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| Authors: | ZHANG Xiru GAO Yanxi JIANG Jianguo SUN Ting |
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| Institution: | Hebei Provincial Institute for Drug Control, Shijiazhuang 050011, China |
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| Abstract: | OBJECTIVE Norfloxacin intra-gastric floating sustained-release tablets were formulated and the in vitro release was studied. METHODS The in vitro release was determined and the effects of formulation factors were investigated. The data were analyzed by th |
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| Keywords: | norfloxacin intra-gastric floating sustained-release tablets formula in vitro release |
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