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nm23基因在人胰腺癌中的表达及其意义
引用本文:何春,徐美荣,池鸣鸣.nm23基因在人胰腺癌中的表达及其意义[J].中国普外基础与临床杂志,2002,9(4):263-264.
作者姓名:何春  徐美荣  池鸣鸣
作者单位:江苏省南通医学院附属医院普外科,南通,226001
摘    要:目的:探讨nm23/NDPK癌基因在胰腺癌组织中的表达及其临床意义。方法:采用免疫组化SP法,对40例胰腺癌组织及14例正常胰腺组织进行nm23/NDPK癌基因检测。结果:40例胰腺癌组织中有26例nm23/NDPK表达阳性,占65.0%;14例正常胰腺组织中仅4例nm23/NDPK表达阳性,占28.6%,两者差异有显著性意义(P<0.05)。低分化腺癌nm23/NDPK表达阳性率为90.9%,明显高于高分化胰腺癌(25.0%),P<0.05。nm23/NDPK表达阳性率在淋巴结转移阳性者为71.4%(10/14),明显高于淋巴结转移阴性者(31.6%,6/19),P<0.05。提示胰腺癌nm23/NDPK表达与淋巴结转移及肿瘤侵袭性呈正相关,与癌组织的分化程度呈负相关。结论:nm23/NDPK表达可作为胰腺癌恶性程度及预后不良的生物学指标之一。

关 键 词:胰腺肿瘤  nm23基因  免疫组织化学  表达  NDPK
文章编号:1007-9424(2002)04-0263-02
修稿时间:2001年4月4日

Expression and Significance of nm23 /NDPK in Pancreatic Adenocarcinomas
HE Chun,XU Mei rong,CHI Ming ming.Expression and Significance of nm23 /NDPK in Pancreatic Adenocarcinomas[J].Chinese Journal of Bases and Clinics In General Surgery,2002,9(4):263-264.
Authors:HE Chun  XU Mei rong  CHI Ming ming
Institution:HE Chun,XU Mei rong,CHI Ming ming. Department of General Surgery,Affiliated Hospital,Nantong Medical College,Nantong 226001
Abstract:Objective To study the expression and clinic significance of nm23 gene (product of uncleoside ciphosphate kinase) in the pancreatic adenocarcinoma tissues. Methods S P immunohistochemical method was used to examine the expression of nm23/NDPK in 40 pancreatic adenocarcinoma and 14 normal pancreas tissues.Results Twenty six of 40(65%) pancreatic adenocarcinoma showed strong immunoreactivity for NDP kinase, whereas 4 of 14 (28.5%) normal pancreatic tissues showed weak immunoreactivity. Significant difference was found between the two groups ( P <0.05). The nm23/NDPK expression levels in pancreatic adenocarcinoma of lower differentiation was higher than those in pancreatic adenocarcinoma of higher differentiation (10/11,90.9%; 2/8, 25%; P <0.05). Positive staining was associated with higher incidence of lymph node metastasis (10/14, 71.4%) than negative staining (6/19,31.5%, P <0.05). These results suggested that nm23/NDPK expression was positively associated with lymph node metastasis and aggressiveness. They also suggested that nm23/NDPK expression had negative correlation with the extent of histologic differentiation. Conclusion nm23/NDPK can serve as a marker for malignant potentiality and indicate the prognosis of pancreatic adenocarcinoma.
Keywords:Pancreatic neoplasm    nm23 gene    Immunohistochemical
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