舒腰灵冲剂的药理作用和临床疗效

目的探讨舒腰灵冲剂主治腰椎间盘突出症的治疗效果及其作用机制。方法与结果通过动物实验证明，舒腰灵冲剂小鼠一次灌胃最大耐受量为12g／kg，并且具有明显抗角叉菜胶致大鼠实验性足跖炎性肿胀，降低乙酸引起小鼠腹腔毛细血管通透性增高，减轻乙酸引起小鼠致痛作用，以及减低全血粘度和红细胞压积作用。另外通过61例腰椎间盘突出症采用日服舒腰灵冲剂治疗，优良率达90．3％。结论舒腰灵冲剂具有明显抗炎止痛和改善血液流变学作用，对临床腰椎间盘突出症有较好疗效。

Pharmacological Action and Clinical Therapeutic Effect of Shu Yao Ling Granules

Aim To inquire into the therapeutic effect of Shu Yao Lin granules (SYL), a modified traditional Chinese medicine, on prolapse of lumbar intervertebral disc and the mechanism of its pharmacological action. Methods and Results (1) In animal experiments, it was demonstrated that SYL showed very low toxicity with maximal tolerant dose o f 12g/kg in mice, SYL significantly inhibited carrageenan-induced inflammatory edema in rat's paw, and significantly inhibited the increase of capillary permeability and abated the pain both induced by intraperitoneal injection of acetic acid into mice. SYL also decreased the whole blood viscosity and erythrocyte compression volume in mice. (2) Clinically, 61 cases of lumbar disc herniation were treated with SYL and the excellent-good rate reached 90. 3%. Conclusion SYL possesses various pharmacological actions, including anti-inflammation, relief of pain, and improvement in blood rheology, with better clinical therapeutic effect against lumbar disc herniaton.