左卡尼汀治疗急性心肌梗死PCI术后患者的临床观察

目的:观察急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)术后予以左卡尼汀治疗的临床疗效。方法:在我院住院的60例急性心肌梗死行PCI术后的患者,随机分为观察组和对照组,对照组予以抗凝及抗缺血治疗,观察组在常规治疗的基础上加用左卡尼汀。检测术前及术后肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白T(cTnT)、脑钠肽(BNP)水平,术前及术后2周心脏B超检查。结果:左卡尼汀组CK-MB、cTnT及血浆BNP水平较对照组下降明显,差异有统计学意义(P<0.05);心脏指数(CI)、左室射血分数(LVEF)治疗后均较对照组有明显改善,差异具有统计学意义(P<0.05)。结论:左卡尼汀对心肌具有保护作用,对急性心肌梗死PCI术后的患者使用具有重要的临床意义。

Clinical study of left-carnitine in patients with acute myocardial infarction after undergoing percutaneous coronary intervention

Objective: To observe the effects of left-carnitine in patients with acute myocardial infarction(AMI) after undergoing percutaneous coronary intervention(PCI).Methods: A total of 60 patients with AMI underwent PCI were randomly divided into observation group and treatment group,Both groups were given conventional anticoagulant and anti-ischemic therapy,while the treatment group was also given extra left-carnitine.The concentration of creatine kinase(CK-MB),troponin(cTnT),brain natriuretic peptide(BNP) were detected before and after undergoing PCI.Ultrasonic cardiogram were conducted in both groups.Results: The level of CK-MB,cTnT,BNP of the treatment group were decreased after undergoing PCI comparing with the control group(P<0.05).LVEF and CI were improved and were better than that of the control group(P<0.05).Conclusion:Left-carnitine has cardio protection effects and can be used in patients with AMI after undergoing PCI.