黄芩茎叶总黄酮调血脂作用及其机制的研究

目的:观察黄芩茎叶总黄酮(SSTF)对实验性高脂血症大鼠脂代谢的影响,初步探讨SSTF降脂机制。方法:在建立大鼠高脂血症模型基础上,观察SSTF对大鼠血脂水平、脂蛋白代谢酶、抗氧化能力等方面的影响。结果:SSTF能显著降低高脂血症大鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)浓度,显著升高高密度脂蛋白胆固醇(HDL-C)和ApoAI浓度,提高血清卵磷脂胆固醇酰基转移酶(LCAT)的活性。SSTF能显著降低血清和肝脏丙二醛(MDA)含量,增加血清超氧化物歧化酶(SOD)的活性。结论:SSTF能明显调节高脂血症大鼠脂质代谢紊乱,对脂蛋白有一定的调节作用。提示SSTF可减少动脉粥样硬化的发生,其调脂机制初步认为与提高脂蛋白代谢酶LCAT的活性和提高抗氧化能力有关。

Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism

Objective: To investigate the effect and mechanism of Scutellaria Baicalensis Stem-leaf Total Flavonoid(SSTF) on lipid metabolism in hyperlipidemic rat.Method: On the basis of establishing hyperlipidemia rat model,blood lipids,lipid metabolic enzyme,antioxidative capacity were investigated after 30 days feeding of fatty emulsion.Result: SSTF significantly reduced the serum TC,TG,LDL-C, ApoB concentration and increased HDL-C and ApoAI levels,improved the activity of lecithin cholesterol acyltransferase(LCAT).SSTF was shown to decreased MDA content in both serum and liver,increased serum SOD activity.Conclusion: SSTF could remarkably modulate the lipid metabolic disorder in hyperlipidemic rats,and has a certain regulating function on lipoprotein,inferring that it could reduce the occuring of atherosclerosis.The mechanism of regulating lipid metabolism might be related with the increasing activity of LCAT and antioxidative capacity.