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| MMP-3在咬合创伤牙周组织中的表达 | |
| 引用本文： | 陈宁,丛长虹,杨清岭.MMP-3在咬合创伤牙周组织中的表达[J].天津医科大学学报,2007,13(1):78-80. |
| 作者姓名： | 陈宁 丛长虹 杨清岭 |
| 作者单位： | 1. 天津医科大学口腔医学院儿童口腔科,天津,300070 2. 天津医科大学口腔医学院口腔颌面外科,天津,300070 3. 佳木斯大学口腔医学院儿童口腔科 |
| 摘 要： | 目的:探讨基质金属蛋白酶-3(MMP-3)在咬合创伤牙周组织的表达和意义。方法:通过在Wistar大鼠左侧上颌第一磨牙粘结高出咬合面的牙本质固位钉建立咬合创伤动物模型,应用免疫组织化学方法观察咬合创伤后24h、3、7、15和30d MMP-3在牙周组织的表达。结果:咬合创伤后,随着病变程度不断加重,MMP-3在牙周组织的表达逐渐增强,咬合创伤15d时MMP-3的表达达到最强,咬合创伤1个月时,MMP-3的表达有所下降。结论:MMP-3可能在咬合创伤牙周组织的破坏过程中起重要作用。 |
| 关 键 词： | 咬合创伤 基质金属蛋白酶 牙周组织 |
| 文章编号： | 1006-8147（2007）01-0078-03 |
| 收稿时间： | 2006-10-26 |
| 修稿时间： | 2006年10月26 |
Expression of MMP-3 in periodontium with traumatic occlusion |
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| CHEN Ning,CONG Chang-hong,YANG Qing-ling.Expression of MMP-3 in periodontium with traumatic occlusion[J].Journal of Tianjin Medical University,2007,13(1):78-80. | |
| Authors: | CHEN Ning CONG Chang-hong YANG Qing-ling |
| Institution: | 1. Department of Pediatric Dentistry, School of Stomatology, Tianjin Medical University, Tianjin 300070, China; 2. Department of Oral and Maxillofacial Surgery, School of Stomatology, Tianjin Medical University; 3. Department of Pediatric Dentistry, School of Stomatology, Jiamusi University |
| Abstract: | Objective: To investigate the expression and the role of MMP-3 in periodontium with traumatic occlusion.Methods: traumatic occlusion animal models were established by bonding self-shearing pin to the upper left molars which exceeded the occlusal surface,and the expression of MMP-3 in periodontium were observed with immunohistochemistry at 24 hours,3 days,7 days,15 days and 30 days after traumatic occlusion.Results: Expression of MMP-3 in periodontium with traumatic occlusion increased and reached the top at 15 days which accompanied the degeneration of the periodontium.Conclusion: MMP-3 may play an important role in the degeneration of the periodontium with traumatic occlusion. |
| Keywords: | Traumatic occlusion Matrix metalloproteinase Periodontium |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |