Glutathione S-transferase M1 polymorphism and esophageal cancer risk: An updated meta-analysis based on 37 studies |
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Authors: | Quan-Jun Lu Ya-Cong Bo Yan Zhao Er-Jiang Zhao Wolde Bekalo Sapa Ming-Jie Yao Dan-Dan Duan Yi-Wei Zhu Wei-Quan Lu Ling Yuan |
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Affiliation: | Quan-Jun Lu;Ya-Cong Bo;Yan Zhao;Er-Jiang Zhao;Wolde Bekalo Sapa;Ming-Jie Yao;Dan-Dan Duan;Yi-Wei Zhu;Wei-Quan Lu;Ling Yuan;Department of Nutrition and Food Hygiene,College of Public Health,Zhengzhou University;Department of Epidemiology and Biostatistics,College of Public Health,Zhengzhou University;Affiliated Tumor Hospital of Zhengzhou University,Henan Tumor Hospital;School of Basic Medical Sciences,Peking University;Department of Radiotherapy,Affiliated Tumor Hospital of Zhengzhou University,Henan Tumor Hospital; |
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Abstract: | AIM: To evaluate the relationship between glutathione S-transferase M1(GSTM1) polymorphism and susceptibility to esophageal cancer(EC).METHODS: A comprehensive search of the United States National Library of Medicine Pub Med database and the Elsevier, Springer, and China National Knowledge Infrastructure databases for all relevant studies was conducted using combinations of the following terms: "glutathione S-transferase M1", "GSTM1", "polymorphism", and "EC"(until November 1, 2014). The statistical analysis was performed using the SAS software(v.9.1.3; SAS Institute, Cary, NC, United States) and the Review Manager software(v.5.0; Oxford, England); crude odds ratios(ORs) with 95% confidence intervals(CIs) were used to assess the association between the GSTM1 null genotype and the risk of EC.RESULTS: A total of 37 studies involving 2236 EC cases and 3243 controls were included in this metaanalysis. We observed that the GSTM1 null genotype was a significant risk factor for EC in most populations(OR = 1.33, 95%CI: 1.12-1.57, P_(heterogeneity) 0.000001, and I2 = 77.0%), particularly in the Asian population(OR = 1.53, 95%CI: 1.26-1.86, P_(heterogeneity) 0.000001, and I2 = 77.0%), but not in the Caucasian population(OR = 1.02, 95%CI: 0.87-1.19, P_(heterogeneity) = 0.97, and I2 = 0%).CONCLUSION: The GSTM1 null polymorphism may be associated with an increased risk for EC in Asian but not Caucasian populations. |
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Keywords: | Meta-analysis Glutathione S-transferase M1 Polymorphism Esophageal cancer Deletions |
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