| 霉酚酸酯在肾移植患者中的应用 |
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| 引用本文： | 徐红冰,寿佳慧,归成,陶亚菊,李灿明.霉酚酸酯在肾移植患者中的应用[J].中国临床药学杂志,2001,10(3):153-155. |
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| 作者姓名： | 徐红冰 寿佳慧 归成 陶亚菊 李灿明 |
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| 作者单位： | 1. 上海市第一人民医院药剂科
2. 上海市第一人民医院肾移植科 |
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| 摘 要： | 目的：将免疫抑制剂霉酚酸酯（MMF）在预防肾移植术后的排斥反应及肝毒性发生率等指标与硫唑嘌呤（Aza）进行临床对照观察。方法：MMF组（环孢素A＋泼尼松＋MMF）35例，对照组（环孢素A＋泼尼松＋Aza)25例。试验观察期24mo。结果：MMF组移植术后排斥反应及肝毒性发生率明显低于对照组，2组差异有高度统计学意义（P肝＜0．01，P肾＜0．01）；且MMF组肾功能较对照组平稳。结论：MMF与环孢素A及泼尼松三药联用，可降低急慢性排斥反应及肝肾毒性发生率，从而提高了免疫抑制剂应用的安全性和耐受性。
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| 关 键 词： | 霉酚酸酯 硫唑嘌呤 环孢素A 排斥反应 肝毒性 CsA MMF |
| 文章编号： | 1007-4406(2001)03-0153-03 |
Application of mycophenolate mofetil in renal transplantation patients |
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| Xu Hongbing ,Shou Jiahui ,Gui Cheng ,Tao Yaju ,Li Canming.Application of mycophenolate mofetil in renal transplantation patients[J].Chinese Journal of Clinical Pharmacy,2001,10(3):153-155. |
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| Authors: | Xu Hongbing Shou Jiahui Gui Cheng Tao Yaju Li Canming |
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| Institution: | Xu Hongbing 1,Shou Jiahui 1,Gui Cheng 1,Tao Yaju 1,Li Canming 2 |
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| Abstract: | AIM: To compare the effects of the immunoinhibition of mycophenolate mofetil (MMF) between MMF group and control group. METHODS: The renal transplantation patients were divided into 2 groups: MMF group (cyclosporin A+prednisone+MMF); control group (cyclosporin A+prednisone+Azathioprine), the 2 groups were studied for 2 y. RESULTS: The incidence of acute rejection and hepatic toxicity of MMF group were belower to control group obviously ( P <0 01). CONCLUSION: MMF group (cyclosporin A+prednisone+MMF) may reduce incidence of acute rejection and hepatic toxicity, and improve safety of immunoinhibitor. |
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| Keywords: | mycophenolate mofetil azathioprine cyclosporin A rejection hepatic toxicity |
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