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Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles |
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| Authors: | Koike Tomonari Wang Xiaofei Unoki Hiroyuki Liang Jingyan Ichikawa Tomonaga Kitajima Shuji Watanabe Teruo Fan Jianglin |
| Institution: | Cardiovascular Disease Laboratory, Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305-8575, Japan. |
| Abstract: | Lipoprotein lipase (LPL) plays an important role in plasma lipoprotein metabolism and the uptake of free fatty acid in muscle. Previous studies using transgenic mice showed that increased LPL leads to myopathies, but these results were controversial. To examine this hypothesis, we studied LPL transgenic rabbits, and our results refute the suggested role of LPL in the pathogenesis of myopathies. |
| Keywords: | free fatty acids lipids lipoprotein lipase lipoprotein metabolism myopathies transgenic |
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