Q开关1064nm Nd:YAG激光联合珍珠美白散治疗黄褐斑疗效探讨

目的:探讨Q开关1064nm Nd:YAG激光联合珍珠美白散治疗黄褐斑的临床疗效。方法:选取2016年4月-2019年4月在笔者医院接受治疗的黄褐斑患者110例作为研究对象,采用随机数字表法将其分为观察组(n=56)和对照组(n=54)。观察组采用Q开关1064nm Nd:YAG激光联合珍珠美白散治疗,对照组采用Q开关1064nm Nd:YAG激光治疗。对比两组临床疗效、皮损总积分、积分下降指数、不良反应率及复发率。结果:治疗后,观察组临床总有效率明显高于对照组(92.86 vs 66.67)%(P<0.05);观察组皮损总积分明显低于对照组(1.27±0.26 vs 2.87±0.38)分,且积分下降指数明显高于对照组(0.66±0.07 vs 0.52±0.06)(P<0.05);观察组不良反应率明显低于对照组(3.57 vs 53.70)%(P<0.05);观察组复发率明显低于对照组(1.79 vs 18.52)%(P<0.05)。结论:Q开关1064nm Nd:YAG激光联合珍珠美白散治疗黄褐斑临床疗效理想,有效改善皮损状况,且对降低复发率及不良反应率效果显著,值得在临床上推广及应用。

Study on the Clinical Effi cacy of Q Switch 1064nm Nd:YAG Laser Combined with Pearl Whitening Powder in the Treatment of Chloasma

Objective To Study on the clinical effi cacy of Q switch 1064nm Nd:YAG laser combined with pearl whitening powder in the treatment of chloasma.Methods 110 cases of chloasma patients who received treatment in our hospital from April 2016 to April 2019 were selected as the study subjects,and were divided into observation group(n=56)and control group(n=54)by random number table method.The observation group was treated with Q switch 1064nm Nd:YAG laser combined with pearl whitening powder,while the control group was treated with q-switch 1064nm Nd:YAG laser.The clinical effi cacy,total score of skin lesions,index of decline in score,adverse reaction rate and recurrence rate were compared between the two groups.Results After treatment,the total clinical effective rate of the observation group was signifi cantly higher than that of the control group(92.86vs66.67)%(P<0.05).The total score of skin lesions in the observation group was signifi cantly lower than that in the control group(1.27±0.26 vs 2.87±0.38),and the index of decline was signifi cantly higher than that in the control group(0.66±0.07vs 0.52±0.06)(P<0.05).The adverse reaction rate in the observation group was signifi cantly lower than that in the control group(3.57 vs 53.70)%(P<0.05).The recurrence rate in the observation group was signifi cantly lower than that in the control group(1.79 vs 18.52)%(P<0.05).Conclusion Q switch 1064nm Nd:YAG laser combined with pearl whitening powder has an ideal clinical effect in the treatment of chloasma,which can effectively improve the condition of skin lesions and signifi cantly reduce the recurrence rate and adverse reaction rate.Therefore,it is worth promoting and applying in clinical practice.