30%超分子水杨酸与低浓度甘醇酸在轻中度寻常性痤疮治疗中的疗效评价

目的:比较30%超分子水杨酸与低浓度甘醇酸治疗轻中度寻常性痤疮的疗效。方法:对2018年1月-2019年6月就诊于中国人民解放军总医院第一医学中心的86例轻、中度寻常性痤疮患者分别进行水杨酸或甘醇酸治疗,其中甘醇酸组48例,水杨酸组38例,共治疗3次,每次间隔时间2~3周,第1次治疗时、第2次治疗时、第3次治疗时及第3次治疗后4周随访(分别为V0、V1、V2、V3),记录患者痤疮分级、粉刺、炎性丘疹、脓疱、结节及GAGS评分。结果:V0时水杨酸治疗组粉刺17.00(13.00, 61.00)个、炎性丘疹32.00 (17.00, 67.00)个、 GAGS评分14.50 (14.00, 16.00)分;V0时甘醇酸治疗组粉刺24.50(11.00,44.00)个、炎性丘疹27.00(19.50,37.50)个、GAGS评分14.00(13.00,18.00)分。V3时水杨酸治疗组粉刺8.00(5.00,19.00)个、炎性丘疹20.00(10.00,22.00)个、GAGS评分11.00(9.00,13.00)分。V3时甘醇酸治疗组粉刺8.50(3.00, 21.00)个、炎性丘疹13.50 (10.00, 21.50)个、GAGS评分11.00 (9.50, 12.50)分。超分子水杨酸和低浓度甘醇酸两组间有效率及GAGS评分差异无统计学意义(P>0.05),两组内V3较V0皮疹减退率、有效率及GAGS评分差异均有统计学意义(P<0.05)。炎性丘疹方面甘醇酸组在治疗2次后较基线比差异有统计学意义,而水杨酸组在治疗3次后较基线比差异有统计学意义,两组治疗过程中均未出现明显不良反应。结论:30%超分子水杨酸与低浓度甘醇酸在轻中度寻常性痤疮治疗中均有效,在炎性丘疹治疗方面甘醇酸起效更快,但水杨酸的安全性略高。

Efficacy Evaluation of 30% Supramolecular Salicylic Acid and Low Concentration Glycolic Acid in the Treatment of Mild to Moderate Acne Vulgaris

Objective Comparison of the efficacy of 30% supramolecular salicylic acid and low concentration glycolic acid in the treatment of mild to moderate acne vulgaris. Methods 86 patients with mild to moderate acne vulgaris who were treated at the General Hospital of PLA from January 2018 to June 2019 were treated with salicylic acid or glycolic acid. 48 patients in the glycolic acid group and 38 patients in the salicylic acid group were treated for 3 times, each interval of 2-3 weeks. At the first treatment, the second treatment, the third treatment, and 4 weeks follow-up after the third treatment, the patients were recorded as V0, V1, V2, and V3. The patient’s acne grade, comedo, inflammatory papules, pustules, nodules, and GAGS scores were recorded separately. Results Salicylic acid V0:comedo 17.00(13.00, 61.00), inflammatory papules 32.00(17.00, 67.00), GAGS scores 14.00(13.00, 18.00). Glycolic acid V0:comedo 24.50(11.00, 44.00), inflammatory papules 27.00(19.50, 37.50), GAGS scores 14.00(13.00, 18.00). Salicylic acid V3:comedo 8.00(5.00, 19.00), inflammatory papules 20.00(10.00, 22.00), GAGS scores 11.00(9.00, 13.00). Glycolic acid V3:comedo 8.50(3.00, 21.00), inflammatory papules 13.50(10.00, 21.50), GAGS scores 11.00(9.50, 12.50). There was no significant difference in the efficiency and GAGS score between the two groups of supramolecular salicylic acid and low concentration glycolic acid(P>0.05). There were significant differences in rash reduction rate, effective rate and GAGS score between V3 and V0 within each group(P<0.05). In the inflammatory papules, the glycolic acid group had a statistically significant difference from the baseline after 2 treatments, while the salicylic acid group had a statistically significant difference from the baseline after 3 treatments. No significant adverse reactions occurred during the treatment of the two groups. Conclusion 30% supramolecular salicylic acid and low concentration of glycolic acid were effective in the treatment of mild to moderate acne, and glycolic acid works faster in the treatment of inflammatory papules. Salicylic acid is slightly safer.