补肾疏肝化瘀方联合Q开关1 064nm激光对黄褐斑患者MASI评分和血液流变学的影响

目的:探究补肾疏肝化瘀方联合Q开关1 064nm激光对黄褐斑患者血液流变学和黄褐斑面积及严重程度积分(MASI)的影响。方法:选取2016年4月-2018年4月于笔者科室诊治的80例黄褐斑患者为研究对象,随机分为对照组和观察组,每组40例,两组患者均给予Q开关1 064nm激光治疗,观察组在此基础上加用补肾疏肝化瘀方。比较并观察两组患者血液流变学、MASI评分、临床疗效、治疗满意度、不良反应及复发情况。结果:观察组总有效率为92.50%,显著高于对照组(75.00%),P<0.05。随访1年,观察组患者复发率为5.00%,对照组为22.50%,观察组显著低于对照组(P<0.05)。观察组患者治疗满意度为85.00%,对照组为65.00%,观察组显著高于对照组(P<0.05)。治疗后两组患者MASI评分、血液黏度、全血黏度低切和高切水平均降低,观察组患者水平显著低于对照组,差异具有统计学意义(P<0.05)。两组患者不良反应发生情况均无统计学意义(P>0.05)。结论:在Q开关1 064nm激光治疗的基础上加用补肾疏肝化瘀方治疗黄褐斑,患者不良反应少,且对患者血液流变学和症状改善更为显著,复发率也更低。

Effect of Bushenshuganhuayu Recipe Combined with Q-switch 1064nm Laser on Hemorheology and the Score of MASI of Patients with Chloasma

Objective To explore the effect of Bushenshuganhuayu Recipe combined with Q-switch 1064 nm laser on hemorheology and the score of melasma area severity index(MASI)of patients with chloasma.Methods 80 patients with chloasma who were diagnosed and treated in the dermatology department of our hospital between April 2016 and April 2018 were randomly divided into the control group and the observation group,with 40 patients in each group.Both groups were treated with Q-switch 1064 nm laser.On this basis,the observation group was additionally treated with Bushenshuganhuayu Recipe.The hemorheology,the score of MASI,clinical efficacy,treatment satisfaction,adverse reactions and recurrence were compared and observed between the two groups.Results The total effective rate in the observation group was 92.50%,significantly higher than that in the control group(75.00%,P<0.05).During a one-year follow-up,the recurrence rate in the observation group was 5.00%,that in the control group was 22.50%,that in the observation group was significantly lower than that in the control group(P<0.05).The patients'satisfaction with treatment in the observation was 85.00%,that in the control group was 65.00%,and that in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the score of MASI,and the levels of blood viscosity,whole blood viscosity low cut and high cut in the two groups were decreased,and those in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in adverse reactions between the control group and the observation group(P>0.05).Conclusion On the basis of Q-switch 1064 nm laser therapy,the addition of Bushenshuganhuayu Recipe does not increase the adverse reactions of patients,and has more significant improvement on hemorheology and symptoms of patients with lower recurrence rate.