优选砂仁油滴丸成型工艺

目的优选砂仁油滴丸的成型工艺。方法采用正交设计法,对滴丸制备过程中基质配比、滴管内径、挥发油与基质的比例、冷却温度等因素进行考察。通过测定滴丸重量差异,溶散时限以及对滴丸进行外观评价,气相色谱法测定砂仁油滴丸中主要有效成分乙酸龙脑酯的含量,综合确定其最佳成型工艺。结果最佳成型工艺条件为：选择PEG6000/PEG4000（1∶1）为基质,滴管内径为2.0mm,挥发油与基质配比为（1∶2）,冷却温度为0～5℃（冰水浴中）。结论此工艺制备的砂仁油滴丸,每丸中乙酸龙脑酯含量高、滴丸重量差异、溶散时限以及外观评价各指标均达到或优于中国药典2005年版一部要求。

Study on Preparing Process Technology of Amomum Villosum Volatile Oil Dropping Pills

OBJECTIVE To study on the process technology of Amomum villosum volatile oil dropping pills.METHODS Orthogonal test was applied to select the optimum extraction parameters including percentage of the base,internal diameter of dropper,proportion of base to volatile oil,and cooling temperature.The optimal process technology was confirmed by the content of bornyl acetate which was determined by GC,weight difference,dissolution time and exterior of Amomum villosum volatile oil dropping pills.RESULTS The optimized process was as follows：the ratio of PEG4000 to PEG6000 was 1∶1,internal diameter of dropper was 2.0 mm,proportion of base to volatile oil was 2∶1 and cooling temperature was 0？5 ℃.CONCLUSION Amomum villosum volatile oil dropping pills which were produced by the optimal process technology were rich in bornyl acetate,and their weight difference,dissolution time as well as exterior met the requirements of Chinese Pharmacopoeia（2005 Edition）.