| 葛根素固体分散体的制备及大鼠体内生物利用度研究 |
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| 引用本文： | 龚显峰,李述溪,赵学玲,李强.葛根素固体分散体的制备及大鼠体内生物利用度研究[J].黑龙江医药,2009,22(2):157-160. |
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| 作者姓名： | 龚显峰 李述溪 赵学玲 李强 |
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| 作者单位： | 黑龙江大学化学化工与材料学院,150080 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目 |
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| 摘 要： | 本文采用新型的固体分散体技术，将葛根素，磷脂与PVP制成固体分散体，对其理化性质进行研究，考察固体分散体在大鼠体内的药一时曲线，计算其在大鼠体内的药动学参数，并与葛根素原料比较，研究固体分散体的相对生物利用度。结果表明以磷脂和PVP为载体制备的固体分散体（药物-磷脂-PVP，2：4：1）的表观油水分配系数最好，固体分散体相对生物利用度较纯葛根素提高了2．53倍。
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| 关 键 词： | 葛根素 固体分散体 生物利用度 |
Preparation and in Vivo Absorption in Rats of Puerarin Solid Dispersion |
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| Institution: | Gong Xianfeng, et al (Dept.of Pharmacy, School of Chemistry and Materials Science, (Heilongjiang University, Harbin 150080) ) |
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| Abstract: | The Puerarin was prepared using phospholipid and PVP as carriers and in vivo absorption in rats were investigated. The present research focuses on the reaction mechanism of Pueraria-phos- pholipid solid dispersion and its physicochemical and biological characterstics. Study the plasma concentration-time curve and phamcokinetic parameters and then the relative hioavilability was compared with puerarin and solid dispersion. The results show the apparent partition coefficient of the solid dispersion with phospholipid and PVP （drug-phospholipid-PVP, 2：4：1） as carrier was satisfactory. The relative bioavailability of solid at dispersion is higher 2.53 times than puerarin. |
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| Keywords: | puerarin solid dispersion bioavailability |
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